Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 18/20 | 0.79 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL602993 | 1.00 | DGAT1 (0.79) | DGAT1RXFP1MEN1NPC1RAB9A | |
| SCHEMBL601178 | 0.92 | DGAT1 (0.77) | DGAT1 | |
| SCHEMBL601177 | 0.92 | DGAT1 (0.77) | DGAT1 | |
| SCHEMBL601275 | 0.89 | DGAT1 (1.00) | DGAT1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL601276 | 0.89 | DGAT1 (1.00) | DGAT1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL601918 | 0.87 | DGAT1 (0.65) | DGAT1RXFP1MEN1NPC1RAB9A | |
| SCHEMBL601917 | 0.87 | DGAT1 (0.65) | DGAT1RXFP1MEN1NPC1RAB9A | |
| SCHEMBL601089 | 0.87 | DGAT1 (0.69) | DGAT1RXFP1MEN1NPC1RAB9A | |
| SCHEMBL602149 | 0.83 | DGAT1 (0.64) | DGAT1RXFP1MEN1NPC1RAB9A | |
| SCHEMBL602148 | 0.83 | DGAT1 (0.64) | DGAT1RXFP1MEN1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8546391-B2 | Thiadiazole and oxadiazole derivatives, preparation thereof and therapeutic use thereof | SANOFI (FR) | 2013-10-01 | — | — | US | disclosed |
| US-20120040984-A1 | THIADIAZOLE AND OXADIAZOLE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120040984-A1 | THIADIAZOLE AND OXADIAZOLE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | OXA1L, CYP11B2, CYP11B1 | DGAT1 3495/4885RXFP1 4408/4885MEN1 1432/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.