SCHEMBL6031381

SCHEMBL6031381

Oc1nc(Cl)nc(Cl)n1.[KH]

nearest known ligand 0.57

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.57
ALOX15 P16050 1/20 0.57
TSHR P16473 1/20 0.57
LMNA P02545 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL49187 0.96
SCHEMBL8402950 0.93 ALDH1A1 (0.57) ALDH1A1ALOX15TSHRLMNA
SCHEMBL29445507 0.93 ALDH1A1 (0.57) ALDH1A1ALOX15TSHRLMNA
SCHEMBL32062 0.93 ALDH1A1 (0.57) ALDH1A1ALOX15TSHRLMNA
SCHEMBL11419308 0.93 ALDH1A1 (0.57) ALDH1A1ALOX15TSHRLMNA
SCHEMBL10604599 0.90 ALDH1A1 (0.53) ALDH1A1ALOX15TSHR
SCHEMBL1425946 0.89
SCHEMBL7902931 0.86 ALDH1A1 (0.47) ALDH1A1ALOX15TSHRLMNA
Hydrochloric Acid SCHEMBL16371430 0.86 ALDH1A1 (0.57) ALDH1A1ALOX15TSHRLMNA
SCHEMBL11141558 0.80 ALDH1A1 (0.42) ALDH1A1ALOX15TSHRLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1463774-B1 NAPHTHYLTRIAZINES AS STABILIZERS FOR ORGANIC MATERIAL BASF SE (DE) 2013-07-31 EP disclosed
US-7087753-B2 Naphthyltriazines as stabilizers for organic material CIBA SPECIALTY CHEMICALS CORP. (US) 2006-08-08 US disclosed
US-20050169859-A1 Naphthyltriazines as stabilizers for organic material TOAN VIEN V (CH) 2005-08-04 US disclosed
US-20050038245-A1 Naphthyltriazines as stabilizers for organic material CIBA SPECIALTY CHEMICALS CORP. 2005-02-17 US disclosed
EP-1463774-A1 NAPHTHYLTRIAZINES AS STABILIZERS FOR ORGANIC MATERIAL Ciba SC Holding AG (CH) 2004-10-06 EP disclosed
US-6800676-B2 ULTRAVIOLET RADIATION ABSORBERS; HEAT AND OXIDATION RESISTANCE CIBA SPECIALTY CHEMICALS CORPORATION 2004-10-05 US disclosed
EP-1112258-B1 METHOD FOR PRODUCING A STABILIZED AQUEOUS ALKALI METAL-2-HYDROXY-4,6-DICHLORO-S-TRIAZINE SOLUTION AND THE USE THEREOF DEGUSSA (DE) 2004-02-04 EP disclosed
US-6570011-B1 Stabilization using 2-hydroxy-4,6-dichloro-s-triazine; hardening gelatin; for photography DEGUSSA AG (DE) 2003-05-27 US disclosed
EP-1305297-A1 BENZOTRIAZOLES CONTAINING ALPHA-CUMYL GROUPS SUBSTITUTED BY HETEROATOMS AND COMPOSITIONS STABILIZED THEREWITH Ciba SC Holding AG (CH) 2003-05-02 EP disclosed
WO-2003035734-A1 NAPHTHYLTRIAZINES AS STABILIZERS FOR ORGANIC MATERIAL CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2003-05-01 WO disclosed
US-20030004235-A1 Benzotriazoles containing phenyl groups substituted by heteroatoms and compositions stabilized therewith CIBA SPECIALTY CHEMICALS CORP. 2003-01-02 US disclosed
US-6489383-B1 SUCH AS 2-(2-HYDROXY-3-(1,1-DI(4-2-(BROMOETHOXY)PHENYL) ETHYL)-5-TERT-BUTYLPHENYL)-2H-BENZOTRIAZOLE FOR USE AS STOVING LACQUER, FINISHING ENAMEL FOR AUTOMOBILES CIBA SPECIALTY CHEMICALS CORPORATION 2002-12-03 US disclosed
US-20020169239-A1 2H-benzotriazole UV absorbers substituted with 1,1-diphenylakyl groups and compositions stabilized therewith WOOD MERVIN G (US) 2002-11-14 US disclosed
US-6451887-B1 Benzotriazoles containing α-cumyl groups substituted by heteroatoms and compositions stabilized therewith CIBA SPECIALTY CHEMICALS CORPORATION 2002-09-17 US disclosed
US-6392056-B1 FOR THERMOPLASTIC RESINS CIBA SPECIALTY CHEMICAL CORPORATION 2002-05-21 US disclosed
WO-2002012205-A1 BENZOTRIAZOLES CONTAINING α-CUMYL GROUPS SUBSTITUTED BY HETEROATOMS AND COMPOSITIONS STABILIZED THEREWITH CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2002-02-14 WO disclosed
WO-2002012204-A1 2H-BENZOTRIAZOLE UV ABSORBERS SUBSTITUTED WITH 1,1-DIPHENYLALKYL GROUPS AND COMPOSITIONS STABILIZED THEREWITH CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2002-02-14 WO disclosed
EP-1112258-A1 METHOD FOR PRODUCING A STABILIZED AQUEOUS ALKALI METAL-2-HYDROXY-4,6-DICHLORO-S-TRIAZINE SOLUTION AND THE USE THEREOF SKW Trostberg Aktiengesellschaft (DE) 2001-07-04 EP disclosed
WO-2000015619-A1 METHOD FOR PRODUCING A STABILIZED AQUEOUS ALKALI METAL-2-HYDROXY-4,6-DICHLORO-S-TRIAZINE SOLUTION AND THE USE THEREOF SKW TROSTBERG AKTIENGESELLSCHAFT (DE) 2000-03-23 WO disclosed
EP-0373797-A1 Azo dyes and use thereof as image dyes in photographic silver dye bleach materials ILFORD AG (CH) 1990-06-20 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020169239-A1 2H-benzotriazole UV absorbers substituted with 1,1-diphenylakyl groups and compositions stabilized therewith SUV39H1, SUV39H2, PAH ALDH1A1 85/4885ALOX15 2812/4885TSHR 4384/4885
US-20050038245-A1 Naphthyltriazines as stabilizers for organic material POT1, TYR, H1-2 ALDH1A1 375/4885ALOX15 2070/4885TSHR 1105/4885
US-20050169859-A1 Naphthyltriazines as stabilizers for organic material POT1, H1-2, TYR ALDH1A1 275/4885ALOX15 1989/4885TSHR 967/4885
US-20030004235-A1 Benzotriazoles containing phenyl groups substituted by heteroatoms and compositions stabilized therewith SUV39H1, SUV39H2, TPST2 ALDH1A1 831/4885ALOX15 2463/4885TSHR 4042/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.