Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 19/20 | 0.58 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.41 |
| ▸ | UCHL3 | P15374 | 1/20 | 0.41 |
| ▸ | UCHL5 | Q9Y5K5 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2710647 | 0.93 | ROCK2 (0.67) | ROCK2 | |
| SCHEMBL13387778 | 0.93 | ROCK2 (0.67) | ROCK2 | |
| SCHEMBL13555523 | 0.89 | ROCK2 (0.59) | ROCK2 | |
| SCHEMBL6032453 | 0.88 | ROCK2 (0.47) | ROCK2UCHL1UCHL3UCHL5 | |
| SCHEMBL2725762 | 0.86 | ROCK2 (0.58) | ROCK2 | |
| SCHEMBL2728611 | 0.86 | ROCK2 (0.58) | ROCK2 | |
| SCHEMBL2725767 | 0.86 | ROCK2 (0.58) | ROCK2 | |
| SCHEMBL2727995 | 0.85 | ROCK2 (0.68) | ROCK2 | |
| SCHEMBL2727997 | 0.85 | ROCK2 (0.68) | ROCK2 | |
| SCHEMBL2729740 | 0.85 | ROCK2 (0.55) | ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120270868-A1 | RHO KINASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-10-25 | — | — | US | disclosed |
| WO-2012054367-A1 | RHO KINASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-04-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120270868-A1 | RHO KINASE INHIBITORS | ROCK1, ROCK2, RHOA | ROCK2 2/4885UCHL1 4692/4885UCHL3 4439/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.