Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 19/20 | 0.47 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.42 |
| ▸ | UCHL3 | P15374 | 1/20 | 0.42 |
| ▸ | UCHL5 | Q9Y5K5 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2726225 | 0.91 | ROCK2 (0.54) | ROCK2 | |
| SCHEMBL6032666 | 0.88 | ROCK2 (0.45) | ROCK2 | |
| SCHEMBL6031827 | 0.88 | ROCK2 (0.58) | ROCK2UCHL1UCHL3UCHL5 | |
| SCHEMBL6031649 | 0.86 | ROCK2 (0.50) | ROCK2 | |
| SCHEMBL6031918 | 0.84 | ROCK2 (0.53) | ROCK2 | |
| SCHEMBL6033337 | 0.83 | ROCK2 (0.61) | ROCK2 | |
| SCHEMBL2729740 | 0.82 | ROCK2 (0.55) | ROCK2 | |
| SCHEMBL6032831 | 0.82 | ROCK2 (0.51) | ROCK2 | |
| SCHEMBL2710647 | 0.81 | ROCK2 (0.67) | ROCK2 | |
| SCHEMBL13387778 | 0.81 | ROCK2 (0.67) | ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012054367-A1 | RHO KINASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-04-26 | — | — | WO | disclosed |