Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | HAO1 | Q9UJM8 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.37 |
| ▸ | FEN1 | P39748 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1748176 | 0.86 | GAA (0.40) | SMN1; SMN2MAPTL3MBTL1DGAT1ALDH1A1 | |
| SCHEMBL1748034 | 0.76 | SMN1; SMN2 (0.44) | SMN1; SMN2MAPTL3MBTL1ALDH1A1HAO1 | |
| SCHEMBL13752563 | 0.76 | NPC1 (0.54) | SMN1; SMN2MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL4428955 | 0.76 | ALDH1A1 (0.50) | SMN1; SMN2MAPTALDH1A1KDM4EMEN1 | |
| SCHEMBL5005972 | 0.75 | TAAR1 (0.37) | SMN1; SMN2MAPTALDH1A1KDM4EHDAC1 | |
| SCHEMBL5067991 | 0.75 | RAB9A (0.50) | SMN1; SMN2MAPTALDH1A1USP2MEN1 | |
| SCHEMBL13752572 | 0.74 | RAB9A (0.58) | SMN1; SMN2MAPTALDH1A1HPGDHDAC1 | |
| SCHEMBL17570995 | 0.74 | MAPT (0.48) | SMN1; SMN2MAPTL3MBTL1ALDH1A1HPGD | |
| SCHEMBL4226915 | 0.73 | RAB9A (0.50) | SMN1; SMN2MAPTDGAT1ALDH1A1KDM4E | |
| SCHEMBL13752741 | 0.72 | RAB9A (0.54) | SMN1; SMN2ALDH1A1MEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633722-A2 | PREPARATION AND USE OF ARYL ALKYL ACID DERIVATIVES FOR THE TREATMENT OF OBESITY | Bayer Pharmaceuticals Corporation (US) | 2006-03-15 | — | — | EP | disclosed |
| WO-2004100881-A2 | PREPARATION AND USE OF ARYL ALKYL ACID DERIVATIVES FOR THE TREATMENT OF OBESITY | BAYER PHARMACEUTICALS CORPORATION (US) | 2004-11-25 | — | — | WO | disclosed |