SCHEMBL6032053

SCHEMBL6032053

CCc1ncc(OC)c2c1CCN(Cc1ccc(F)cc1)C2=O

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 6/20 0.49
SMN1; SMN2 Q16637 5/20 0.49
HTT P42858 4/20 0.49
L3MBTL1 Q9Y468 3/20 0.49
ALDH1A1 P00352 3/20 0.49
KMT2A Q03164 3/20 0.48
MEN1 O00255 2/20 0.48
TDP1 Q9NUW8 1/20 0.48
NCOA3 Q9Y6Q9 1/20 0.47
PDE4B Q07343 5/20 0.43
PDE4A P27815 4/20 0.43
PDE4C Q08493 4/20 0.43
PDE4D Q08499 4/20 0.43
MAPK1 P28482 2/20 0.39
MAPT P10636 1/20 0.39
AKR1B1 P15121 1/20 0.38
POLB P06746 2/20 0.38
HCRTR2 O43614 2/20 0.38
RECQL P46063 1/20 0.38
WDR5 P61964 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4487053 0.86 LMNA (0.50) LMNASMN1; SMN2HTTL3MBTL1ALDH1A1
SCHEMBL4478643 0.83 LMNA (0.47) LMNASMN1; SMN2HTTL3MBTL1ALDH1A1
SCHEMBL4479504 0.83 SMN1; SMN2 (0.48) LMNASMN1; SMN2HTTL3MBTL1ALDH1A1
SCHEMBL4477132 0.82 LMNA (0.50) LMNASMN1; SMN2HTTL3MBTL1ALDH1A1
SCHEMBL4489537 0.81 LMNA (0.45) LMNASMN1; SMN2HTTL3MBTL1ALDH1A1
SCHEMBL4494682 0.80 LMNA (0.45) LMNASMN1; SMN2HTTL3MBTL1ALDH1A1
SCHEMBL4482031 0.77 P2RX7 (0.44) LMNASMN1; SMN2HTTL3MBTL1ALDH1A1
SCHEMBL4492762 0.74 EGLN1 (0.47) LMNASMN1; SMN2HTTALDH1A1KMT2A
SCHEMBL4551107 0.73 TNIK (0.39) LMNASMN1; SMN2HTTL3MBTL1ALDH1A1
SCHEMBL2728496 0.73 EGLN1 (0.44) LMNASMN1; SMN2HTTL3MBTL1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1725556-A1 HIV INTEGRASE INHIBITORS Merck & Co., Inc. (US) 2006-11-29 EP disclosed
WO-2005087768-A1 HIV INTEGRASE INHIBITORS MERCK & CO., INC. (US) 2005-09-22 WO disclosed
WO-2005087767-A1 HIV INTEGRASE INHIBITORS MERCK & CO., INC. (US) 2005-09-22 WO disclosed