Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A1 | P43005 | 4/20 | 0.51 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.51 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.51 |
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.50 |
| ▸ | ALPI | P09923 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | XIAP | P98170 | 1/20 | 0.50 |
| ▸ | ANPEP | P15144 | 1/20 | 0.47 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.47 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.47 |
| ▸ | GRIK1 | P39086 | 3/20 | 0.47 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.44 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.44 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27278334 | 0.87 | ALPI (0.60) | SLC1A1SLC1A3SLC1A2SLC7A5ALPI | |
| SCHEMBL29179537 | 0.85 | PNMT (0.47) | SLC1A1SLC1A3SLC1A2SLC7A5GRIK1 | |
| SCHEMBL23249510 | 0.82 | GRIK1 (0.56) | SLC1A1SLC1A3SLC1A2SLC7A5ALPI | |
| SCHEMBL27170852 | 0.80 | SLC7A5 (0.62) | SLC1A1SLC1A3SLC1A2SLC7A5ALPI | |
| SCHEMBL9341151 | 0.80 | SLC7A5 (0.62) | SLC1A1SLC1A3SLC1A2SLC7A5ALPI | |
| SCHEMBL7053196 | 0.79 | ITGB1 (0.57) | SLC1A1SLC1A3SLC1A2 | |
| SCHEMBL8530260 | 0.79 | SLC1A1 (0.56) | SLC1A1SLC1A3SLC1A2SLC7A5ALPI | |
| SCHEMBL108380 | 0.78 | TSHR (0.49) | TSHR | |
| SCHEMBL4117169 | 0.78 | SLC15A1 (0.59) | SLC1A1SLC1A3SLC1A2SLC7A5ALPI | |
| SCHEMBL7303521 | 0.78 | SLC15A1 (0.59) | SLC1A1SLC1A3SLC1A2SLC7A5ALPI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7033781-B1 | Whole cell engineering by mutagenizing a substantial portion of a starting genome, combining mutations, and optionally repeating | DIVERSA CORPORATION (US) | 2006-04-25 | — | — | US | disclosed |
| US-20050124010-A1 | Whole cell engineering by mutagenizing a substantial portion of a starting genome combining mutations and optionally repeating | DIVERSA CORPORATION | 2005-06-09 | — | — | US | disclosed |
| EP-1415160-A2 | WHOLE CELL ENGINEERING BY MUTAGENIZING A SUBSTANTIAL PORTION OF A STARTING GENOME, COMBINING MUTATIONS, AND OPTIONALLY REPEATING | DIVERSA CORPORATION (US) | 2004-05-06 | — | — | EP | disclosed |
| US-20040077090-A1 | Whole cell engineering by mutagenizing a substantial portion of a starting genome, combining mutations, and optionally repeating | SHORT JAY M (US) | 2004-04-22 | — | — | US | disclosed |
| EP-1294869-A2 | WHOLE CELL ENGINEERING BY MUTAGENIZING A SUBSTANTIAL PORTION OF A STARTING GENOME, COMBINING MUTATIONS, AND OPTIONALLY REPEATING | DIVERSA CORPORATION (US) | 2003-03-26 | — | — | EP | disclosed |
| WO-2002029032-A2 | WHOLE CELL ENGINEERING BY MUTAGENIZING A SUBSTANTIAL PORTION OF A STARTING GENOME, COMBINING MUTATIONS, AND OPTIONALLY REPEATING | DIVERSA CORPORATION (US) | 2002-04-11 | — | — | WO | disclosed |
| WO-2001096551-A2 | WHOLE CELL ENGINEERING BY MUTAGENIZING A SUBSTANTIAL PORTION OF A STARTING GENOME, COMBINING MUTATIONS, AND OPTIONALLY REPEATING | DIVERSA CORPORATION (US) | 2001-12-20 | — | — | WO | disclosed |
| US-6033823-A | Mutated penicillin G acylase genes | DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V., (NL) | 2000-03-07 | — | — | US | disclosed |
| EP-0775210-B1 | MUTATED PENICILLIN G ACYLASE GENES | DSM NV (NL) | 2000-02-02 | — | — | EP | disclosed |
| EP-0906418-A4 | — | — | 1999-05-06 | — | — | EP | disclosed |
| EP-0906418-A1 | METHODS AND COMPOSITIONS FOR CELLULAR AND METABOLIC ENGINEERING | Maxygen, Inc. (US) | 1999-04-07 | — | — | EP | disclosed |
| US-5891703-A | Mutated penicillin G acylase genes | GIST-HROCADES (NL) | 1999-04-06 | — | — | US | disclosed |
| US-5695978-A | CULTURE PRODUCT | GIST-BROCADES, N.V. (NL) | 1997-12-09 | — | — | US | disclosed |
| WO-1997035966-A1 | METHODS AND COMPOSITIONS FOR CELLULAR AND METABOLIC ENGINEERING | MAXYGEN, INC. (US) | 1997-10-02 | — | — | WO | disclosed |
| EP-0775210-A1 | MUTATED PENICILLIN G ACYLASE GENES | GIST-BROCADES B.V. (NL) | 1997-05-28 | — | — | EP | disclosed |
| WO-1996005318-A1 | MUTATED PENICILLIN G ACYLASE GENES | GIST-BROCADES B.V. (NL) | 1996-02-22 | — | — | WO | disclosed |
| EP-0453047-B1 | Penicillin G acylase, a gene encoding the same and a method for the production of this enzyme | GIST BROCADES NV (NL) | 1995-07-05 | — | — | EP | disclosed |
| US-5168048-A | Genetic engineering of Alcaligenes | GIST-BROCADES NV (NL) | 1992-12-01 | — | — | US | disclosed |
| EP-0453047-A1 | Penicillin G acylase, a gene encoding the same and a method for the production of this enzyme | GIST-BROCADES N.V. (NL) | 1991-10-23 | — | — | EP | disclosed |