Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 4/20 | 0.47 |
| ▸ | HTR3E | A5X5Y0 | 6/20 | 0.41 |
| ▸ | HTR3B | O95264 | 6/20 | 0.41 |
| ▸ | HTR3A | P46098 | 6/20 | 0.41 |
| ▸ | HTR3D | Q70Z44 | 6/20 | 0.41 |
| ▸ | HTR3C | Q8WXA8 | 6/20 | 0.41 |
| ▸ | SLC22A2 | O15244 | 2/20 | 0.41 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.41 |
| ▸ | SLC22A3 | O75751 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HGFAC | Q04756 | 3/20 | 0.35 |
| ▸ | CES2 | O00748 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.34 |
| ▸ | NOS1 | P29475 | 2/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nitric Acid SCHEMBL6034160 | 0.85 | PLAU (0.47) | PLAUHTR3EHTR3BHTR3AHTR3D | |
| Nitric Acid SCHEMBL6034777 | 0.81 | PLAU (0.53) | PLAUHTR3EHTR3BHTR3AHTR3D | |
| Nitric Acid SCHEMBL11561556 | 0.78 | PLAU (0.49) | PLAUHTR3EHTR3BHTR3AHTR3D | |
| Nitric Acid SCHEMBL4613845 | 0.77 | PLAU (0.73) | PLAUHTR3EHTR3BHTR3AHTR3D | |
| Nitric Acid SCHEMBL5034246 | 0.77 | HTR3E (0.48) | PLAUHTR3EHTR3BHTR3AHTR3D | |
| Nitric Acid SCHEMBL6034257 | 0.76 | ITGB3 (0.60) | PLAUHTR3EHTR3BHTR3AHTR3D | |
| Nitric Acid SCHEMBL3859434 | 0.76 | PLAU (0.51) | PLAUHTR3EHTR3BHTR3AHTR3D | |
| Nitric Acid SCHEMBL1363670 | 0.75 | HTR3E (0.48) | PLAUHTR3EHTR3BHTR3AHTR3D | |
| Nitric Acid SCHEMBL6034737 | 0.74 | HTR3E (0.55) | PLAUHTR3EHTR3BHTR3AHTR3D | |
| Nitric Acid SCHEMBL2910175 | 0.74 | HTR3E (0.61) | PLAUHTR3EHTR3BHTR3AHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1187816-B1 | 5-CYANO-2-AMINOPYRIMIDINE DERIVATIVES | CELLTECH R&D LTD (GB) | 2006-12-20 | — | — | EP | disclosed |
| US-20040180914-A1 | 5-Cyano-2-aminopyrimidine derivatives | CELLTECH R&D LIMTIED | 2004-09-16 | — | — | US | disclosed |
| US-6579983-B1 | Potent and selective inhibitors of receptor tyrosine kinases involved in angiogenesis, especially KDR kinase and/or FGFr kinase | CELLTECH R&D LIMITED (GB) | 2003-06-17 | — | — | US | disclosed |
| US-20020147339-A1 | 5-cyano-2-aminopyrimidine derivatives | CELLTECH R&D LIMITED (GB) | 2002-10-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040180914-A1 | 5-Cyano-2-aminopyrimidine derivatives | FLT1, FGFR1, KDR | PLAU 3039/4885HTR3E 1499/4885HTR3B 1512/4885 |
| US-20020147339-A1 | 5-cyano-2-aminopyrimidine derivatives | FLT1, FGFR1, KDR | PLAU 3100/4885HTR3E 1249/4885HTR3B 1267/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.