Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 7/20 | 0.50 |
| ▸ | RAB9A | P51151 | 6/20 | 0.50 |
| ▸ | NPC1 | O15118 | 6/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
| ▸ | GPR3 | P46089 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5435508 | 0.80 | RAB9A (0.49) | HTTRAB9ANPC1NPSR1RXFP1 | |
| SCHEMBL7048629 | 0.79 | NCF1 (0.55) | HTTRAB9ANPC1NPSR1RXFP1 | |
| Hydrochloric Acid SCHEMBL28590788 | 0.78 | NCF1 (0.53) | HTTRAB9ANPC1NPSR1RXFP1 | |
| SCHEMBL28585105 | 0.74 | PDE10A (0.47) | HTTRAB9ANPC1NPSR1RXFP1 | |
| Hydrochloric Acid SCHEMBL28608866 | 0.73 | PDE10A (0.46) | HTTRAB9ANPC1NPSR1RXFP1 | |
| SCHEMBL13557874 | 0.73 | RAB9A (0.50) | HTTRAB9ANPC1NPSR1RXFP1 | |
| SCHEMBL13557867 | 0.73 | KDM4E (0.47) | HTTRAB9ANPC1ALDH1A1KMT2A | |
| SCHEMBL14582925 | 0.72 | PDE10A (0.44) | HTTRAB9ANPC1NPSR1RXFP1 | |
| SCHEMBL4526835 | 0.71 | HTT (0.68) | HTTRAB9ANPC1NPSR1RXFP1 | |
| SCHEMBL13557884 | 0.71 | RAB9A (0.48) | HTTRAB9ANPC1NPSR1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1687642-A2 | ANTI-VASCULAR AND ANTI-PROLIFERATION METHODS, THERAPIES, AND COMBINATIONS EMPLOYING SPECIFIC TYROSINE KINASE INHIBITORS | CENTELION (FR) | 2006-08-09 | — | — | EP | disclosed |
| WO-2005038465-A2 | ANTI-VASCULAR AND ANTI-PROLIFERATION METHODS, THERAPIES, AND COMBINATIONS EMPLOYING SPECIFIC TYROSINE KINASE INHIBITORS | CENTELION (FR) | 2005-04-28 | — | — | WO | disclosed |