Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | NT5E | P21589 | 1/20 | 0.59 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.59 |
| ▸ | AHCY | P23526 | 6/20 | 0.58 |
| ▸ | NADK | O95544 | 1/20 | 0.58 |
| ▸ | DNMT1 | P26358 | 2/20 | 0.55 |
| ▸ | DNMT3B | Q9UBC3 | 2/20 | 0.55 |
| ▸ | CA5A | P35218 | 1/20 | 0.53 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.53 |
| ▸ | PNMT | P11086 | 1/20 | 0.51 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2047953 | 0.96 | ADORA3 (0.66) | ADORA3LMNANT5EHIF1AAHCY | |
| SCHEMBL19849513 | 0.88 | ADORA3 (0.77) | ADORA3LMNANT5EHIF1AAHCY | |
| SCHEMBL5362972 | 0.88 | ADORA3 (0.77) | ADORA3LMNANT5EHIF1AAHCY | |
| SCHEMBL2404114 | 0.88 | ADORA3 (0.77) | ADORA3LMNANT5EHIF1AAHCY | |
| SCHEMBL2048909 | 0.85 | NT5E (0.81) | ADORA3LMNANT5EHIF1ADNMT1 | |
| SCHEMBL2405804 | 0.84 | ADORA3 (0.66) | ADORA3AHCYNADKDNMT1DNMT3B | |
| SCHEMBL2047948 | 0.82 | AHCY (0.59) | ADORA3AHCYNADKADORA2ADOT1L | |
| SCHEMBL2405234 | 0.82 | AHCY (0.59) | ADORA3AHCYNADKADORA2ADOT1L | |
| SCHEMBL2405239 | 0.82 | AHCY (0.59) | ADORA3AHCYNADKADORA2ADOT1L | |
| SCHEMBL6035105 | 0.82 | AHCY (0.59) | ADORA3AHCYNADKADORA2ADOT1L |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1444335-A4 | MUTANT PURINE NUCLEOSIDE PHOSPHORYLASE PROTEINS AND CELLULAR DELIVERY THEREOF | UAB RESEARCH FOUNDATION (US) | 2006-03-08 | — | — | EP | disclosed |
| EP-1444335-A2 | MUTANT PURINE NUCLEOSIDE PHOSPHORYLASE PROTEINS AND CELLULAR DELIVERY THEREOF | UAB Research Foundation (US) | 2004-08-11 | — | — | EP | disclosed |
| WO-2003035012-A2 | MUTANT PURINE NUCLEOSIDE PHOSPHORYLASE PROTEINS AND CELLULAR DELIVERY THEREOF | UAB RESEARCH FOUNDATION (US) | 2003-05-01 | — | — | WO | disclosed |