Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.50 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.49 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.49 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CTRC | Q99895 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 3/20 | 0.44 |
| ▸ | PTGES | O14684 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5695098 | 0.96 | TSHR (0.52) | TSHRPRSS1PRSS2PRSS3KDM4E | |
| SCHEMBL6035268 | 0.91 | TSHR (0.51) | TSHRPRSS1PRSS2PRSS3KDM4E | |
| SCHEMBL6036105 | 0.89 | TSHR (0.49) | TSHRPRSS1PRSS2PRSS3KDM4E | |
| SCHEMBL6034422 | 0.88 | SLC6A3 (0.47) | TSHRPRSS1PRSS2PRSS3KDM4E | |
| SCHEMBL5695131 | 0.87 | TSHR (0.53) | TSHRPRSS1PRSS2PRSS3KDM4E | |
| SCHEMBL2517738 | 0.87 | KDM4E (0.57) | TSHRPRSS1PRSS2PRSS3KDM4E | |
| SCHEMBL28658873 | 0.86 | PRSS1 (0.53) | TSHRPRSS1PRSS2PRSS3KDM4E | |
| SCHEMBL19717843 | 0.85 | KDM4E (0.56) | TSHRPRSS1PRSS2PRSS3KDM4E | |
| SCHEMBL547407 | 0.85 | KDM4E (0.56) | TSHRPRSS1PRSS2PRSS3KDM4E | |
| SCHEMBL3674655 | 0.85 | KDM4E (0.56) | TSHRPRSS1PRSS2PRSS3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6984741-B2 | 5-Nitrobenzofurans | BAYER AKTIENGESELLSCHAFT (DE) | 2006-01-10 | — | — | US | disclosed |
| US-20050288519-A1 | 5-Nitrobenzofurans | MAGERLEIN WOLFGANG | 2005-12-29 | — | — | US | disclosed |
| CN-1485323-A | 5-nitrobenzofurans | — | 2004-03-31 | — | — | CN | disclosed |
| US-20040034220-A1 | 5-Nitrobenzofurans | LANXESS DEUTSCHLAND GMBH (DE) | 2004-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050288519-A1 | 5-Nitrobenzofurans | NOX5, NQO1, NDUFS5 | TSHR 4324/4885PRSS1 3855/4885PRSS2 3096/4885 |
| US-20040034220-A1 | 5-Nitrobenzofurans | NOX5, NQO1, NDUFS5 | TSHR 4324/4885PRSS1 3855/4885PRSS2 3096/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.