Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 7/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.40 |
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | MC4R | P32245 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1266729 | 0.90 | MAPT (0.46) | MEN1KMT2AMAPTALDH1A1HPGD | |
| SCHEMBL5648088 | 0.73 | MAPT (0.49) | MEN1KMT2AMAPTALDH1A1HPGD | |
| SCHEMBL5651378 | 0.72 | ALDH1A1 (0.50) | MEN1KMT2AMAPTALDH1A1HPGD | |
| SCHEMBL2948992 | 0.70 | DHODH (0.51) | MEN1KMT2AMAPTALDH1A1HPGD | |
| SCHEMBL5653775 | 0.69 | CDC7 (0.41) | MEN1KMT2AMAPTALDH1A1HPGD | |
| SCHEMBL2956431 | 0.67 | DHODH (0.46) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL3491232 | 0.67 | KDM4E (0.46) | MEN1KMT2AMAPTHDAC4HDAC6 | |
| SCHEMBL25205219 | 0.65 | ALDH1A1 (0.43) | MEN1KMT2AMAPTALDH1A1HPGD | |
| SCHEMBL31015983 | 0.65 | ALDH1A1 (0.43) | MEN1KMT2AMAPTALDH1A1HPGD | |
| SCHEMBL12895309 | 0.65 | RXFP1 (0.43) | MEN1KMT2AMAPTALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1680429-A1 | THIENO-PYRIDINONE DERIVATIVES AS KINASE INHIBITORS | Celltech R & D Limited (GB) | 2006-07-19 | — | — | EP | disclosed |
| WO-2005042540-A1 | THIENO-PYRIDINONE DERIVATIVES AS KINASE INHIBITORS | CELLTECH R & D LIMITED (GB) | 2005-05-12 | — | — | WO | disclosed |