Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16550634 | 0.86 | TDP1 (0.52) | TDP1ALDH1A1HPGDALOX15ALOX12 | |
| SCHEMBL1271761 | 0.79 | TP53 (0.42) | TDP1ALDH1A1LOXL2TP53 | |
| SCHEMBL15125416 | 0.78 | TDP1 (0.56) | TDP1ALDH1A1HPGDALOX15ALOX12 | |
| SCHEMBL9076653 | 0.78 | TDP1 (0.56) | TDP1ALDH1A1HPGDALOX15ALOX12 | |
| SCHEMBL523595 | 0.77 | TDP1 (0.48) | TDP1ALDH1A1HPGDALOX15ALOX12 | |
| SCHEMBL523393 | 0.77 | TDP1 (0.48) | TDP1ALDH1A1HPGDALOX15ALOX12 | |
| SCHEMBL9076841 | 0.77 | TP53 (0.40) | TDP1ALDH1A1LOXL2TP53 | |
| SCHEMBL3653394 | 0.77 | HTR2A (0.54) | TDP1ALDH1A1HPGDALOX15ALOX12 | |
| SCHEMBL3389806 | 0.77 | TDP1 (0.52) | TDP1ALDH1A1HPGDALOX15ALOX12 | |
| SCHEMBL6420860 | 0.77 | TDP1 (0.52) | TDP1ALDH1A1HPGDALOX15ALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6991852-B2 | A silica-based material that includes a silica-based substrate and a polymerized organic material disposed thereon. The polymerized organic material is made from reactive organic moieties bonded to the silica-based substrate. | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2006-01-31 | — | — | US | disclosed |
| US-20030219597-A1 | Silica-based materials and methods | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2003-11-27 | — | — | US | disclosed |
| WO-2003078159-A1 | SILICA-BASED MATERIALS AND METHODS | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2003-09-25 | — | — | WO | disclosed |
| US-5532397-A | Substituted silyl alkylene amines | MERRELL PHARMACEUTICALS INC. (US) | 1996-07-02 | — | — | US | disclosed |
| US-5529988-A | Substituted silyl alkylene amines | MERRELL PHARMACEUTICALS INC. (US) | 1996-06-25 | — | — | US | disclosed |
| US-5384312-A | Substituted silyl alkylene amines | MERRELL DOW PHARMACEUTICALS INC. (US) | 1995-01-24 | — | — | US | disclosed |
| EP-0291787-B1 | Novel substituted silyl alkylene amines | MERRELL DOW PHARMA (US) | 1994-03-16 | — | — | EP | disclosed |
| EP-0291787-A1 | Novel substituted silyl alkylene amines | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-11-23 | — | — | EP | disclosed |