SCHEMBL523595

SCHEMBL523595

C[Si](C)(Cl)CCc1ccccc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 2/20 0.48
ALDH1A1 P00352 2/20 0.44
HPGD P15428 1/20 0.44
ALOX15 P16050 1/20 0.44
ALOX12 P18054 1/20 0.44
CASP1 P29466 1/20 0.44
HSD17B10 Q99714 1/20 0.44
TAAR1 Q96RJ0 3/20 0.43
SMN1; SMN2 Q16637 3/20 0.43
NPC1 O15118 3/20 0.43
RAB9A P51151 3/20 0.43
AOC3 Q16853 2/20 0.43
ATM Q13315 1/20 0.43
KDM1A O60341 1/20 0.43
LMNA P02545 1/20 0.43
CYP1A2 P05177 1/20 0.43
CYP3A4 P08684 1/20 0.43
HTR1A P08908 1/20 0.43
ADRA2A P08913 1/20 0.43
CYP2C8 P10632 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3195033 0.87 LMNA (0.38) TDP1TAAR1NPC1RAB9AAOC3
SCHEMBL523288 0.86 L3MBTL1 (0.45) AOC3HTR1AADRA2AMAOASLC6A2
SCHEMBL523393 0.86 TDP1 (0.48) TDP1ALDH1A1HPGDALOX15ALOX12
SCHEMBL5654858 0.85 L3MBTL1 (0.48) MAOAMAOB
SCHEMBL28731916 0.83 SIGMAR1 (0.50) MAOAMAOB
SCHEMBL16207822 0.83 SIGMAR1 (0.50) MAOAMAOB
SCHEMBL9322667 0.82 TDP1 (0.44) TDP1ALDH1A1HPGDALOX15ALOX12
SCHEMBL16550634 0.80 TDP1 (0.52) TDP1ALDH1A1HPGDALOX15ALOX12
SCHEMBL208903 0.80 TDP1 (0.52) TDP1ALDH1A1HPGDALOX15ALOX12
SCHEMBL6420860 0.80 TDP1 (0.52) TDP1ALDH1A1HPGDALOX15ALOX12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 262 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3218438-B1 WEATHER-RESISTANT, FUNGAL-RESISTANT, AND STAIN-RESISTANT COATINGS AND METHODS OF APPLYING ON WOOD, MASONRY, OR OTHER POROUS MATERIALS UNIV HOUSTON SYSTEM (US) 2020-12-16 EP claimed
CN-111354945-A Negative electrode for secondary lithium metal battery and method for manufacturing same 通用汽车环球科技运作有限责任公司 2020-06-30 CN claimed
CN-107207884-A Weather-proof, antimycotic, anti-coloring pollution coating and the method being applied on timber, masonry material or other porous materials 休斯敦大学系统 2017-09-26 CN claimed
CN-107208354-A Anti-soiling, anti-staining coating and method of applying to textile or other flexible material 休斯敦大学系统 2017-09-26 CN claimed
CN-107109777-A Antifouling, anti-coloring pollution the method applied without fluorine coating and on material 休斯敦大学系统 2017-08-29 CN claimed
WO-2013079939-A2 OSCILLATOR SPRING COMPOSITION AND METHOD FOR FABRICATING AN OSCILLATOR SPRING CARBONTIME LIMITED (GB) 2013-06-06 WO claimed
US-20070087025-A1 Reiteratively layered medical devices and method of preparing same FITZHUGH ANTHONY 2007-04-19 US claimed
US-6822109-B2 TRIHYDROCARBYLSILYLATION; ADDITION POLYMERIZATION OF OLEFINS CHINA PETROLEUM & CHEMICAL CORPORATION (CN) 2004-11-23 US claimed
EP-1436018-A1 NITRIC OXIDE-RELEASING COATED MEDICAL DEVICES AND METHOD OF PREPARING SAME THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2004-07-14 EP claimed
US-20040106814-A1 Silicon ether compound, a method for the preparation thereof and use thereof BEIJING RESEARCH INSTITUTE OF CHEMICAL INDUSTRY, CHINA PETROLEUM & CHEMICAL CORPORATION (CN) 2004-06-03 US claimed
WO-2003026717-A1 NITRIC OXIDE-RELEASING COATED MEDICAL DEVICES AND METHOD OF PREPARING SAME THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2003-04-03 WO claimed
US-6365643-B1 Photoinitiators for cationic curing TH. GOLDSCHMIDT AG (DE) 2002-04-02 US claimed
CN-119608184-A Ball-milling catalytic hydrosilylation reaction method and catalyst used in same 浙江大学 2025-03-14 CN disclosed
CN-119080823-A Method for preparing tetramethylsilane and active siloxane by using low-boiling-point substances 郭兰 2024-12-06 CN disclosed
US-12109812-B2 Ink jet printing method and ink jet printing apparatus SEIKO EPSON CORPORATION (JP) 2024-10-08 US disclosed
EP-3743464-B1 ORGANIC-INORGANIC AEROGEL COMPOSITES, METHODS AND USES THEREOF BRONX CREATIVE&DESIGN CENTRE PTE LTD (SG) 2024-03-06 EP disclosed
US-4824982-A Method for the cleavage of organic siloxanes, and products and applications thereof HUELS TROISDORF AG (DE) 1989-04-25 US disclosed
US-4739021-A Unsaturated silylated vinyl alcohol polymers E. I. DU PONT DE NEMOURS AND COMPANY (US) 1988-04-19 US disclosed
EP-0246053-A1 Unsaturated silylated vinyl alcohol polymers E.I. DU PONT DE NEMOURS AND COMPANY (US) 1987-11-19 EP disclosed
US-4379766-A Silyl esters of carboxylic acids by phase transfer catalysts CONOCO INC. (US) 1983-04-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070087025-A1 Reiteratively layered medical devices and method of preparing same NOS2, NOS1, NOS3 TDP1 1589/4885ALDH1A1 2127/4885HPGD 304/4885
US-20040106814-A1 Silicon ether compound, a method for the preparation thereof and use thereof SIK1, CDK20, SGMS1 TDP1 4834/4885ALDH1A1 2500/4885HPGD 4590/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.