Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 4/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.46 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 8/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 3/20 | 0.38 |
| ▸ | DRD4 | P21917 | 2/20 | 0.38 |
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL613615 | 0.96 | OPRM1 (0.45) | OPRM1OPRK1OPRD1OPRL1TSHR | |
| Ethylene SCHEMBL8880978 | 0.81 | OPRM1 (0.46) | OPRM1OPRK1OPRD1OPRL1DRD2 | |
| Ethylene SCHEMBL16040738 | 0.81 | OPRM1 (0.34) | OPRM1OPRK1OPRD1OPRL1DRD2 | |
| SCHEMBL7824744 | 0.80 | OPRM1 (0.53) | OPRM1OPRK1OPRD1OPRL1TSHR | |
| SCHEMBL612855 | 0.79 | ESR2 (0.43) | DRD2DRD3DRD4CYP1A2CYP3A4 | |
| Ethylene SCHEMBL3235445 | 0.78 | CYP19A1 (0.37) | OPRM1OPRK1OPRD1OPRL1CYP3A4 | |
| SCHEMBL743825 | 0.77 | KMT2A (0.39) | OPRM1OPRK1OPRL1DRD2DRD3 | |
| SCHEMBL613284 | 0.77 | OPRM1 (0.49) | OPRM1OPRK1OPRD1OPRL1DRD2 | |
| SCHEMBL613957 | 0.77 | DRD2 (0.58) | OPRM1OPRK1OPRD1OPRL1TSHR | |
| SCHEMBL15349268 | 0.77 | OPRM1 (0.45) | OPRM1OPRK1OPRD1OPRL1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1414813-B1 | 1,2,4-TRIOXOLANE ANTIMALARIALS | MEDICINES MALARIA VENTURE MMV (CH) | 2006-09-13 | — | — | EP | disclosed |
| US-6906205-B2 | Spiro and dispiro 1,2,4-trioxolane antimalarials | MEDICINES FOR MALARIA VENTURE MMV (CH) | 2005-06-14 | — | — | US | disclosed |
| US-6828341-B2 | Brain disorders; anticonvulsants; central nervous system disorders; psychological disorders | WARNER-LAMBERT COMPANY | 2004-12-07 | — | — | US | disclosed |
| US-20040186168-A1 | Such as spiroadamantane on one side and 4-substituted spiro-cyclohexyl on other side; structurally simple, nontoxic, easy synthesis, potent parasiticides | MEDICINES FOR MALARIA VENTURE MMV (CH) | 2004-09-23 | — | — | US | disclosed |
| EP-1414813-A1 | 1,2,4-TRIOXOLANE ANTIMALARIALS | Medicines for Malaria Venture (CH) | 2004-05-06 | — | — | EP | disclosed |
| WO-2003000676-A1 | 1,2,4-TRIOXOLANE ANTIMALARIALS | MEDICINES FOR MALARIA VENTURE (CH) | 2003-01-03 | — | — | WO | disclosed |
| US-20030004212-A1 | Cyclohexylamine derivatives as subtype selective N-Methyl-D-Aspartate antagonists | DEORAZIO RUSSELL JOSEPH (US) | 2003-01-02 | — | — | US | disclosed |
| US-6486199-B1 | Spiro and dispiro 1,2,4-trioxolane antimalarials | MEDICINES FOR MALARIA VENTURE MMV INTERNATIONAL CENTRE COINTRIN (CH) | 2002-11-26 | — | — | US | disclosed |
| EP-1251128-A1 | Cyclohexylamine derivatives as subtype selective N-methyl-D-aspartate antagonists | WARNER-LAMBERT COMPANY (US) | 2002-10-23 | — | — | EP | disclosed |
| US-5643904-A | Substituted hexahdryoazepinones and tetrahydrobenzazepinones | PFIZER INC. (US) | 1997-07-01 | — | — | US | disclosed |
| US-5484917-A | FOR TREATMENT AND PREVENTION OF GASTROINTESTINAL DISORDERS, PAIN AND ANXIETY | PFIZER INC. (US) | 1996-01-16 | — | — | US | disclosed |
| EP-0625145-A1 | 3-PHENYLUREIDO-AZEPIN-2-ONES AND -BENZAZEPIN-2-ONES USEFUL AS CHOLECYSTOKININ ANTAGONISTS | PFIZER INC. (US) | 1994-11-23 | — | — | EP | disclosed |
| WO-1993015059-A1 | 3-PHENYLUREIDO-AZEPIN-2-ONES AND -BENZAZEPIN-2-ONES USEFUL AS CHOLECYSTOKININ ANTAGONISTS | PFIZER INC. (US) | 1993-08-05 | — | — | WO | disclosed |
| CN-1074903-A | The six hydrogen azepine ketone and the tetrahydro benzo azepine ketone that replace | PFIZER (US) | 1993-08-04 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030004212-A1 | Cyclohexylamine derivatives as subtype selective N-Methyl-D-Aspartate antagonists | GLRB, GRIN1, GRIN2B | OPRM1 4/4885OPRK1 6/4885OPRD1 5/4885 |
| US-20040186168-A1 | Such as spiroadamantane on one side and 4-substituted spiro-cyclohexyl on other side; structurally simple, nontoxic, easy synthesis, potent parasiticides | DHODH, SQLE, SULT1E1 | OPRM1 1933/4885OPRK1 1623/4885OPRD1 932/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.