Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.85 |
| ▸ | CETP | P11597 | 4/20 | 0.58 |
| ▸ | SRC | P12931 | 1/20 | 0.58 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.50 |
| ▸ | ALPG | P10696 | 1/20 | 0.50 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.50 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.48 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.46 |
| ▸ | MTOR | P42345 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL51316 | 0.92 | TSHR (1.00) | TSHRCETPSRCAKR1C3ALPG | |
| SCHEMBL27908642 | 0.92 | TSHR (1.00) | TSHRCETPSRCAKR1C3ALPG | |
| SCHEMBL1404249 | 0.91 | TSHR (0.81) | TSHRCETPSRCAKR1C3ALPG | |
| SCHEMBL11756554 | 0.90 | TSHR (0.96) | TSHRCETPSRCAKR1C3ALPG | |
| SCHEMBL9446520 | 0.90 | TSHR (0.96) | TSHRCETPSRCAKR1C3ALPG | |
| SCHEMBL4219700 | 0.90 | TSHR (0.96) | TSHRCETPSRCAKR1C3ALPG | |
| Hydrochloric Acid SCHEMBL10722992 | 0.90 | TSHR (0.96) | TSHRCETPSRCAKR1C3ALPG | |
| Ammonia Solution, Strong SCHEMBL7268743 | 0.90 | TSHR (0.96) | TSHRCETPSRCAKR1C3ALPG | |
| Phosphoric Acid SCHEMBL27741297 | 0.90 | TSHR (0.96) | TSHRCETPSRCAKR1C3ALPG | |
| SCHEMBL28264490 | 0.90 | TSHR (0.96) | TSHRCETPSRCAKR1C3ALPG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060111274-A1 | Methods and compositions for enhancing transport across biological membranes | THE BOARD OF TRUSTEES OF THE LELAND STANFORD (US) | 2006-05-25 | — | — | US | disclosed |
| EP-0975370-B9 | COMPOSITION AND METHOD FOR ENHANCING TRANSPORT ACROSS BIOLOGICAL MEMBRANES | UNIV LELAND STANFORD JUNIOR (US) | 2004-11-03 | — | — | EP | disclosed |
| EP-0975370-B1 | COMPOSITION AND METHOD FOR ENHANCING TRANSPORT ACROSS BIOLOGICAL MEMBRANES | UNIV LELAND STANFORD JUNIOR (US) | 2003-10-15 | — | — | EP | disclosed |
| US-20030162719-A1 | Method and composition for enhancing transport across biological membranes | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2003-08-28 | — | — | US | disclosed |
| EP-1304122-A2 | Composition and method for enhancing transport across biological membrane | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2003-04-23 | — | — | EP | disclosed |
| WO-2001062297-A9 | COMPOSITIONS AND METHODS FOR ENHANCING DRUG DELIVERY ACROSS BIOLOGICAL MEMBRANES AND TISSUES | CELLGATE INC (US) | 2003-01-09 | — | — | WO | disclosed |
| US-6495663-B1 | A CONJUGATE FOR ADMINISTRATION, TO A MAMMALIAN SUBJECT, OF AN ANTIMICROBIAL AGENT WHOSE EFFICACY IN NON-CONJUGATED FORM IS LIMITED BY ITS SOLUBILITY IN AQUEOUS LIQUID OR ITS INABILITY TO CROSS BIOLOGICAL MEMBRANES TO MANIFEST BIOLOGICAL ACTIVITY, | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2002-12-17 | — | — | US | disclosed |
| EP-1263469-A1 | COMPOSITIONS AND METHODS FOR ENHANCING DRUG DELIVERY ACROSS BIOLOGICAL MEMBRANES AND TISSUES | Cellgate Inc. (US) | 2002-12-11 | — | — | EP | disclosed |
| US-20020131965-A1 | Method for enhancing transport across biological membranes | ROTHBARD JONATHAN R (US) | 2002-09-19 | — | — | US | disclosed |
| US-20020009491-A1 | Compositions and methods for enhancing drug delivery across biological membranes and tissues | PROGEN PHARMACEUTICALS, INC. | 2002-01-24 | — | — | US | disclosed |
| US-6306993-B1 | DELIVERY OF PICLITAXEL ACROSS BIOLOGICAL MEMBRANES ATTACHED TO A LINKER | THE BOARD OF TRUSTEES OF THE LELAND STANFORD, JR. UNIVERSITY | 2001-10-23 | — | — | US | disclosed |
| WO-2001062297-A1 | COMPOSITIONS AND METHODS FOR ENHANCING DRUG DELIVERY ACROSS BIOLOGICAL MEMBRANES AND TISSUES | CELLGATE, INC. (US) | 2001-08-30 | — | — | WO | disclosed |
| CN-1263473-A | Composition and method for enhancing transport across biological membranes | UNIV LELAND STANFORD JUNIOR (US) | 2000-08-16 | — | — | CN | disclosed |
| EP-0975370-A2 | COMPOSITION AND METHOD FOR ENHANCING TRANSPORT ACROSS BIOLOGICAL MEMBRANES | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2000-02-02 | — | — | EP | disclosed |
| WO-1998052614-A2 | COMPOSITION AND METHOD FOR ENHANCING TRANSPORT ACROSS BIOLOGICAL MEMBRANES | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 1998-11-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020009491-A1 | Compositions and methods for enhancing drug delivery across biological membranes and tissues | SLC7A1, ADM2, PGF | TSHR 3753/4885CETP 84/4885SRC 3390/4885 |
| US-20030162719-A1 | Method and composition for enhancing transport across biological membranes | SLC29A1, SLC29A2, SLC47A2 | TSHR 1933/4885CETP 108/4885SRC 3677/4885 |
| US-20060111274-A1 | Methods and compositions for enhancing transport across biological membranes | SLC29A1, SLC29A2, SLC47A2 | TSHR 2106/4885CETP 119/4885SRC 3640/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.