Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | RARB | P10826 | 5/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | PLA2G4B | P0C869 | 7/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10815761 | 0.85 | TDP1 (0.55) | PKMALDH1A1L3MBTL1ALOX15 | |
| SCHEMBL6037802 | 0.83 | PLA2G4B (0.52) | PLA2G4BALDH1A1L3MBTL1ALOX15 | |
| SCHEMBL6037793 | 0.82 | KMT2A (0.60) | PLA2G4BHTT | |
| SCHEMBL27654982 | 0.81 | PKM (0.58) | MAPK1PKMRARBTSHRTP53 | |
| SCHEMBL1952122 | 0.80 | TP53 (0.79) | MAPK1PKMRARBTSHRTP53 | |
| SCHEMBL118037 | 0.80 | PKM (0.77) | MAPK1PKMRARBTSHRTP53 | |
| SCHEMBL6539739 | 0.80 | MAPK1 (0.84) | MAPK1PKMRARBTSHRTP53 | |
| SCHEMBL9634846 | 0.79 | PPARG (0.64) | MAPK1PKMRARBTSHRTP53 | |
| SCHEMBL2180731 | 0.79 | TP53 (0.82) | PKMRARBTSHRTP53PLA2G4B | |
| SCHEMBL14097198 | 0.79 | TP53 (0.82) | PKMRARBTSHRTP53PLA2G4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002057222-A9 | THIOL-BASED NAALADASE INHIBITORS | GUILFORD PHARM INC (US) | 2004-05-06 | — | — | WO | claimed |
| EP-1353903-A2 | THIOL-BASED NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 2003-10-22 | — | — | EP | claimed |
| WO-2002057222-A2 | THIOL-BASED NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 2002-07-25 | — | — | WO | claimed |
| WO-2006093991-A1 | COMPOUNDS WHICH BIND PSMA AND USES THEREOF | THE CLEVELAND CLINIC FOUNDATION (US) | 2006-09-08 | — | — | WO | disclosed |