SCHEMBL6037802

SCHEMBL6037802

O=C(O)Cc1ccc(OCCCC(S)C(=O)O)cc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PLA2G4B P0C869 1/20 0.52
ALDH1A1 P00352 1/20 0.50
LMNA P02545 1/20 0.50
LTB4R Q15722 4/20 0.47
LTB4R2 Q9NPC1 4/20 0.47
ALOX15 P16050 1/20 0.47
TBXAS1 P24557 1/20 0.47
POLB P06746 1/20 0.45
TDP1 Q9NUW8 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.45
FFAR1 O14842 2/20 0.44
KDM4E B2RXH2 1/20 0.44
CYP1A2 P05177 1/20 0.44
CYP2D6 P10635 1/20 0.44
PDE4A P27815 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
HIF1A Q16665 1/20 0.44
HDAC10 Q969S8 1/20 0.44
HDAC6 Q9UBN7 1/20 0.44
ITGB3 P05106 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10815761 0.83 TDP1 (0.55) ALDH1A1ALOX15TDP1L3MBTL1HDAC10
SCHEMBL11684213 0.83 PLA2G4B (0.69) PLA2G4BALDH1A1LMNALTB4RLTB4R2
SCHEMBL6037857 0.83 MAPK1 (0.59) PLA2G4BALDH1A1ALOX15L3MBTL1
SCHEMBL6037841 0.82 PLA2G4B (0.54) PLA2G4BALDH1A1LTB4RTDP1L3MBTL1
SCHEMBL11683055 0.81 PLA2G4B (0.61) PLA2G4BALDH1A1LMNALTB4RLTB4R2
SCHEMBL27655101 0.79 ITGB3 (0.54) LMNAPOLBTDP1L3MBTL1FFAR1
SCHEMBL10728695 0.78 PLA2G4B (0.59) PLA2G4BALDH1A1LMNALTB4RLTB4R2
SCHEMBL1162418 0.78 PLA2G4B (0.59) PLA2G4BALDH1A1LMNALTB4RLTB4R2
SCHEMBL9517972 0.78 LTB4R (0.63) PLA2G4BALDH1A1LMNALTB4RLTB4R2
SCHEMBL8767652 0.78 LTB4R (0.63) PLA2G4BLMNALTB4RLTB4R2ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2002057222-A9 THIOL-BASED NAALADASE INHIBITORS GUILFORD PHARM INC (US) 2004-05-06 WO claimed
EP-1353903-A2 THIOL-BASED NAALADASE INHIBITORS GUILFORD PHARMACEUTICALS INC. (US) 2003-10-22 EP claimed
WO-2002057222-A2 THIOL-BASED NAALADASE INHIBITORS GUILFORD PHARMACEUTICALS INC. (US) 2002-07-25 WO claimed
WO-2006093991-A1 COMPOUNDS WHICH BIND PSMA AND USES THEREOF THE CLEVELAND CLINIC FOUNDATION (US) 2006-09-08 WO disclosed