Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.61 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.60 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.60 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.60 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.60 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.60 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.60 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.60 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.60 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | DRD2 | P14416 | 1/20 | 0.57 |
| ▸ | DRD3 | P35462 | 1/20 | 0.57 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27550290 | 0.80 | AKR1C3 (0.86) | AKR1C3HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL6483696 | 0.77 | AKR1C3 (1.00) | AKR1C3HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL6475009 | 0.77 | AKR1C3 (1.00) | AKR1C3HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL27891708 | 0.76 | KDM4E (0.64) | AKR1C3HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL19837655 | 0.76 | DRD2 (0.90) | AKR1C3HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL6473590 | 0.76 | AKR1C3 (0.78) | AKR1C3HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL6481222 | 0.76 | AKR1C3 (0.78) | AKR1C3HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL19837643 | 0.76 | DRD2 (0.90) | AKR1C3HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL6481636 | 0.76 | AKR1C3 (0.97) | AKR1C3HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL12672868 | 0.75 | HDAC1 (1.00) | AKR1C3HDAC1HDAC2HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060264415-A1 | Inhibitors of histone deacetylase | METHYLGENE INC. | 2006-11-23 | — | — | US | claimed |
| US-20060264415-A1 | Inhibitors of histone deacetylase | METHYLGENE INC. | 2006-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060264415-A1 | Inhibitors of histone deacetylase | HDAC1, HDAC3, HDAC11 | AKR1C3 2200/4885HDAC1 1/4885HDAC2 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.