Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.90 |
| ▸ | DRD3 | P35462 | 1/20 | 0.90 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.78 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.76 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.76 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.76 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.76 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.76 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.76 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.76 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.76 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.76 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.76 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.73 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.71 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.69 |
| ▸ | HTR2C | P28335 | 1/20 | 0.66 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19837655 | 1.00 | DRD2 (0.90) | DRD2DRD3AKR1C3HDAC1HDAC2 | |
| SCHEMBL74104 | 0.94 | DRD2 (1.00) | DRD2DRD3AKR1C3HDAC1HDAC2 | |
| SCHEMBL27550290 | 0.92 | AKR1C3 (0.86) | DRD2DRD3AKR1C3HDAC1HDAC2 | |
| SCHEMBL13753861 | 0.89 | DRD2 (0.84) | DRD2DRD3AKR1C3HDAC1HDAC2 | |
| SCHEMBL6475009 | 0.88 | AKR1C3 (1.00) | DRD2DRD3AKR1C3HDAC1HDAC2 | |
| SCHEMBL6483696 | 0.88 | AKR1C3 (1.00) | DRD2DRD3AKR1C3HDAC1HDAC2 | |
| SCHEMBL6473590 | 0.86 | AKR1C3 (0.78) | DRD2DRD3AKR1C3HDAC1HDAC2 | |
| SCHEMBL6481222 | 0.86 | AKR1C3 (0.78) | DRD2DRD3AKR1C3HDAC1HDAC2 | |
| SCHEMBL6481636 | 0.86 | AKR1C3 (0.97) | DRD2DRD3AKR1C3HDAC1HDAC2 | |
| SCHEMBL7370548 | 0.85 | HDAC1 (0.77) | DRD2DRD3AKR1C3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10383848-B2 | Indole-based therapeutics | CREIGHTON UNIVERSITY (US) | 2019-08-20 | — | — | US | disclosed |
| US-10383848-B2 | Indole-based therapeutics | CREIGHTON UNIVERSITY (US) | 2019-08-20 | — | — | US | disclosed |
| US-20180036283-A1 | INDOLE-BASED THERAPEUTICS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-02-08 | — | — | US | disclosed |
| US-20180036283-A1 | INDOLE-BASED THERAPEUTICS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-02-08 | — | — | US | disclosed |
| US-20180036283-A1 | INDOLE-BASED THERAPEUTICS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-02-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10383848-B2 | Indole-based therapeutics | IDO2, IDO1, INMT | DRD2 2461/4885DRD3 2642/4885AKR1C3 2252/4885 |
| US-20180036283-A1 | INDOLE-BASED THERAPEUTICS | IDO2, IDO1, INMT | DRD2 2461/4885DRD3 2642/4885AKR1C3 2252/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.