Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 9/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6037970 | 0.86 | TP53 (0.54) | TP53LMNAMAPTPOLBRXFP1 | |
| SCHEMBL5286061 | 0.84 | ALDH1A1 (0.55) | TP53LMNAMAPTPOLBALDH1A1 | |
| SCHEMBL5275941 | 0.84 | TP53 (0.55) | TP53LMNAMAPTPOLBRXFP1 | |
| SCHEMBL5289055 | 0.81 | TP53 (0.47) | TP53LMNAMAPTPOLBALDH1A1 | |
| SCHEMBL5284789 | 0.81 | TP53 (0.47) | TP53LMNAMAPTPOLBRXFP1 | |
| SCHEMBL5281003 | 0.81 | TP53 (0.68) | TP53LMNAMAPTPOLBRXFP1 | |
| SCHEMBL5280650 | 0.81 | RAB9A (0.45) | TP53LMNAMAPTRAB9AHDAC1 | |
| SCHEMBL5286194 | 0.81 | TP53 (0.53) | TP53LMNAMAPTALDH1A1GAA | |
| SCHEMBL5282822 | 0.81 | HDAC1 (0.46) | TP53LMNAMAPTRAB9AHDAC1 | |
| SCHEMBL6037972 | 0.80 | TP53 (0.47) | TP53LMNAMAPTPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060264415-A1 | Inhibitors of histone deacetylase | METHYLGENE INC. | 2006-11-23 | — | — | US | claimed |
| US-20060264415-A1 | Inhibitors of histone deacetylase | METHYLGENE INC. | 2006-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060264415-A1 | Inhibitors of histone deacetylase | HDAC1, HDAC3, HDAC11 | TP53 2551/4885LMNA 851/4885MAPT 3848/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.