SCHEMBL6039155

SCHEMBL6039155

COc1ccc(C(OC[C@H]2O[C@@H](n3c(NC(=O)C(C)C)nc4c(O)ncnc43)C[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)(c2ccccc2)c2ccc(OC)cc2)cc1

nearest known ligand 0.33

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
TYMP P19971 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7197818 0.83 KDM4E (0.48) TYMP
SCHEMBL12765886 0.83 KDM4E (0.48) TYMP
SCHEMBL10533862 0.83 KDM4E (0.41) TYMP
SCHEMBL7923594 0.83 TYMP (0.37) TYMP
SCHEMBL6039053 0.82 TYMP (0.44) TYMP
SCHEMBL18486381 0.82 SLC28A2 (0.32)
SCHEMBL18486380 0.82 SLC28A2 (0.32)
SCHEMBL2054229 0.82 TYMP (0.39) TYMP
SCHEMBL29449394 0.82 TYMP (0.39) TYMP
SCHEMBL15786367 0.82 TYMP (0.39) TYMP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060008813-A1 Compositions and methods of synthesis and use of novel nucleic acid structures ERITJA RAMON 2006-01-12 US disclosed
EP-1228243-A4 COMPOSITIONS AND METHODS OF SYNTHESIS AND USE OF NOVEL NUCLEIC ACID STRUCTURES CYGENE INC (US) 2005-07-20 EP disclosed
US-6831072-B2 Such as 8-amino-2'deoxyadenosine by treating 8-azido-2'deoxyadenosine with aqueous solution of methylamine or dimethylamine; for targeting nucleic acids without amplification and less use of enzymes CYGENE, INC. 2004-12-14 US disclosed
US-20030135040-A1 Compositions and methods of synthesis and use of novel nucleic acid structures CYGENE, INC. 2003-07-17 US disclosed
EP-1228243-A1 COMPOSITIONS AND METHODS OF SYNTHESIS AND USE OF NOVEL NUCLEIC ACID STRUCTURES Cygene, Inc. (US) 2002-08-07 EP disclosed
WO-2001032924-A1 COMPOSITIONS AND METHODS OF SYNTHESIS AND USE OF NOVEL NUCLEIC ACID STRUCTURES CYGENE, INC. (US) 2001-05-10 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030135040-A1 Compositions and methods of synthesis and use of novel nucleic acid structures ADAR, NSUN2, RNGTT TYMP 96/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.