Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 17/20 | 0.58 |
| ▸ | DRD2 | P14416 | 4/20 | 0.58 |
| ▸ | HTR2A | P28223 | 4/20 | 0.58 |
| ▸ | HTR7 | P34969 | 4/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6039811 | 0.88 | HTR6 (0.56) | HTR6DRD2HTR2AHTR7CYP3A4 | |
| SCHEMBL29429815 | 0.88 | HTR6 (0.56) | HTR6DRD2HTR2AHTR7CYP3A4 | |
| SCHEMBL20190392 | 0.86 | HTR6 (0.54) | HTR6DRD2HTR2AHTR7CYP3A4 | |
| SCHEMBL6039808 | 0.86 | HTR6 (0.55) | HTR6DRD2HTR2AHTR7CYP3A4 | |
| SCHEMBL28313363 | 0.86 | HTR6 (0.53) | HTR6DRD2HTR2AHTR7CYP3A4 | |
| SCHEMBL517689 | 0.83 | L3MBTL1 (0.57) | HTR6DRD2HTR2AHTR7CYP3A4 | |
| SCHEMBL23152049 | 0.82 | HTR6 (0.49) | HTR6DRD2HTR2AHTR7CYP3A4 | |
| SCHEMBL25219570 | 0.82 | HTR6 (0.50) | HTR6DRD2HTR2AHTR7CYP3A4 | |
| SCHEMBL28312482 | 0.81 | HTR6 (0.48) | HTR6DRD2HTR2AHTR7CYP3A4 | |
| SCHEMBL14719082 | 0.78 | CDK5 (0.52) | CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006038001-A1 | AMINOPYRIMIDINE DERIVATIVES AS JNK INHIBITORS | CELLTECH R & D LIMITED (GB) | 2006-04-13 | — | — | WO | disclosed |