Acridine

Acridine

SCHEMBL6039596

CC(=O)Nc1cccc(/C=C/c2ccc(N=C=S)cc2S(=O)(=O)O)c1S(=O)(=O)O.c1ccc2nc3ccccc3cc2c1

nearest known ligand 0.60

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAD1 O60671 1/20 0.53
P2RY6 Q15077 1/20 0.53
RAD51 Q06609 4/20 0.50
MAPT P10636 5/20 0.41
KDM4E B2RXH2 5/20 0.41
USP2 O75604 2/20 0.41
ALDH1A1 P00352 2/20 0.41
LTA P01374 2/20 0.41
CYP3A4 P08684 2/20 0.41
HPGD P15428 2/20 0.41
P2RX3 P56373 2/20 0.41
HSD17B10 Q99714 2/20 0.41
TDP1 Q9NUW8 2/20 0.41
ENPP2 Q13822 1/20 0.39
SENP2 Q9HC62 5/20 0.38
SENP1 Q9P0U3 5/20 0.38
SENP3 Q9H4L4 4/20 0.38
SUMO2 P61956 3/20 0.38
SUMO1 P63165 3/20 0.38
SENP7 Q9BQF6 3/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acridine SCHEMBL5792145 1.00 RAD1 (0.53) RAD1P2RY6RAD51MAPTKDM4E
SCHEMBL30727492 0.92 P2RY6 (0.63) RAD1P2RY6RAD51MAPTKDM4E
SCHEMBL3130034 0.92 P2RY6 (0.63) RAD1P2RY6RAD51MAPTKDM4E
Acridine SCHEMBL722533 0.87 RAD51 (0.67) RAD1P2RY6RAD51MAPTKDM4E
Acridine SCHEMBL6290391 0.87 RAD51 (0.67) RAD1P2RY6RAD51MAPTKDM4E
Acridine SCHEMBL3232431 0.84 RAD51 (0.64) RAD1P2RY6RAD51MAPTKDM4E
SCHEMBL31475554 0.78 RAD51 (0.60) RAD1P2RY6RAD51MAPTKDM4E
SCHEMBL25796 0.76 RAD51 (0.81) RAD1P2RY6RAD51MAPTKDM4E
SCHEMBL175934 0.76 RAD51 (0.81) RAD1P2RY6RAD51MAPTKDM4E
SCHEMBL29351606 0.76 RAD51 (0.81) RAD1P2RY6RAD51MAPTKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2006083269-A2 LUMINESCENT NANOSENSORS FLORIDA ATLANTIC UNIVERSITY (US) 2006-08-10 WO disclosed