Acridine

Acridine

SCHEMBL722533

CC(=O)Nc1ccc(C=Cc2ccc(N=C=S)cc2S(=O)(=O)O)c(S(=O)(=O)O)c1.c1ccc2nc3ccccc3cc2c1

nearest known ligand 0.81

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAD51 Q06609 4/20 0.67
RAD1 O60671 1/20 0.58
P2RY6 Q15077 1/20 0.58
ENPP2 Q13822 2/20 0.55
APEX1 P27695 1/20 0.49
MAPT P10636 5/20 0.45
KDM4E B2RXH2 4/20 0.45
ALDH1A1 P00352 3/20 0.45
USP2 O75604 2/20 0.45
LTA P01374 2/20 0.45
CYP3A4 P08684 2/20 0.45
HPGD P15428 2/20 0.45
P2RX3 P56373 2/20 0.45
HSD17B10 Q99714 2/20 0.45
TDP1 Q9NUW8 2/20 0.45
MEN1 O00255 3/20 0.45
KMT2A Q03164 3/20 0.45
NPC1 O15118 2/20 0.45
RAB9A P51151 2/20 0.45
PABPC1 P11940 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acridine SCHEMBL6290391 1.00 RAD51 (0.67) RAD51RAD1P2RY6ENPP2APEX1
Acridine SCHEMBL3232431 0.97 RAD51 (0.64) RAD51RAD1P2RY6ENPP2APEX1
SCHEMBL29351606 0.90 RAD51 (0.81) RAD51RAD1P2RY6ENPP2APEX1
SCHEMBL25796 0.90 RAD51 (0.81) RAD51RAD1P2RY6ENPP2APEX1
SCHEMBL175934 0.90 RAD51 (0.81) RAD51RAD1P2RY6ENPP2APEX1
SCHEMBL2333703 0.89 RAD51 (0.80) RAD51RAD1P2RY6ENPP2APEX1
SCHEMBL15823509 0.89 RAD51 (0.80) RAD51RAD1P2RY6ENPP2APEX1
SCHEMBL30160852 0.89 RAD51 (0.80) RAD51RAD1P2RY6ENPP2APEX1
SCHEMBL2333711 0.89 RAD51 (0.80) RAD51RAD1P2RY6ENPP2APEX1
Acridine SCHEMBL5792145 0.87 RAD1 (0.53) RAD51RAD1P2RY6ENPP2APEX1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 98 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1427854-A1 METHODS FOR QUANTIFYING NUCLEAR RUN-ON TRANSCRIPTIONAL ASSAYS Benitec Australia Ltd. (AU) 2004-06-16 EP claimed
WO-2003018832-A1 METHODS FOR QUANTIFYING NUCLEAR RUN-ON TRANSCRIPTIONAL ASSAYS BENITEC AUSTRALIA LTD (AU) 2003-03-06 WO claimed
WO-2023096721-A1 FRET-ACTIVE E2-UBL CONJUGATES AND USES THEREOF BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2023-06-01 WO disclosed
EP-4058580-A1 ENGINEERED GYRI-LIKE MUTEIN APTAMERS, AND RELATED METHODS Crosslife Technologies Inc. (US) 2022-09-21 EP disclosed
WO-2021263188-A9 LIVE CELL ENGAGEMENT ASSAY ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) 2022-06-09 WO disclosed
WO-2021263188-A1 LIVE CELL ENGAGEMENT ASSAY ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) 2021-12-30 WO disclosed
WO-2021096759-A1 ENGINEERED GYRI-LIKE MUTEIN APTAMERS, AND RELATED METHODS CROSSLIFE TECHNOLOGIES INC. (US) 2021-05-20 WO disclosed
US-20210139958-A1 ENGINEERED GYRI-LIKE MUTEIN APTAMERS, AND RELATED METHODS CROSSLIFE TECHNOLOGIES INC. 2021-05-13 US disclosed
US-20200384126-A1 DETECTION OF HIGH RISK DRUSEN SIXTH STREET LENDING PARTNERS 2020-12-10 US disclosed
EP-3268743-B1 COMBINATION TREPONEMAL AND NON-TREPONEMAL SYPHILIS TEST BIO RAD LABORATORIES (US) 2020-09-02 EP disclosed
US-10648981-B2 Combination treponemal and non-treponemal syphilis test BIO-RAD LABORATORIES, INC. (US) 2020-05-12 US disclosed
EP-1250451-A1 OLIGONUCLEOTIDES AND ASSEMBLIES THEREOF USEFUL IN THE DETECTION OF THE PRESENCE OR ABSENCE OF TARGET NUCLEIC ACID SEQUENCES IN A SAMPLE GAMIDA SENSE DIAGNOSTICS LTD. (IL) 2002-10-23 EP disclosed
WO-2002057479-A2 PRIMERS AND METHODS FOR THE DETECTION AND DISCRIMINATION OF NUCLEIC ACIDS INVITROGEN CORPORATION (US) 2002-07-25 WO disclosed
WO-2000079009-A9 IMPROVED PRIMERS AND METHODS FOR THE DETECTION AND DISCRIMINATION OF NUCLEIC ACIDS INVITROGEN CORP (US) 2002-06-13 WO disclosed
WO-2002044399-A2 IN VITRO TRANSCRIPTION METHOD FOR RNA AMPLIFICATION ROSETTA INPHARMATICS, INC. (US) 2002-06-06 WO disclosed
EP-1190097-A2 IMPROVED PRIMERS AND METHODS FOR THE DETECTION AND DISCRIMINATION OF NUCLEIC ACIDS INVITROGEN CORPORATION (US) 2002-03-27 EP disclosed
WO-2001086001-A1 DARK QUENCHERS FOR DONOR-ACCEPTOR ENERGY TRANSFER BIOSEARCH TECHNOLOGIES, INC. (US) 2001-11-15 WO disclosed
US-6271002-B1 A POLYMERASE CHAIN REACTION KIT FOR INCORPORATING AN RNA POLYMERASE PROMOTER INTO DOUBLE STRANDED CDNA BY AMPLIFICATION WITH AN RNA PRIMER FOR LESS THAN 20 CYCLES; THEN THE RNA POLYMERASE CONTAINING CDNA IS THEN TRANSCRIBED INTO RNA ROSETTA INPHARMATICS, INC. 2001-08-07 US disclosed
WO-2001038570-A1 OLIGONUCLEOTIDES AND ASSEMBLIES THEREOF USEFUL IN THE DETECTION OF THE PRESENCE OR ABSENCE OF TARGET NUCLEIC ACID SEQUENCES IN A SAMPLE GAMIDA SENSE DIAGNOSTICS LTD. (IL) 2001-05-31 WO disclosed
WO-2000079009-A2 IMPROVED PRIMERS AND METHODS FOR THE DETECTION AND DISCRIMINATION OF NUCLEIC ACIDS INVITROGEN CORPORATION (US) 2000-12-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200384126-A1 DETECTION OF HIGH RISK DRUSEN IL17A, EXOSC4, CFB RAD51 1352/4885RAD1 3003/4885P2RY6 1709/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.