Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.53 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.53 |
| ▸ | MKNK1 | Q9BUB5 | 17/20 | 0.50 |
| ▸ | MKNK2 | Q9HBH9 | 16/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16140386 | 0.87 | RPS6KA5 (0.67) | RPS6KA5RPS6KA4MKNK1MKNK2 | |
| Benzimidazole SCHEMBL11042413 | 0.76 | HTT (0.70) | — | |
| SCHEMBL6760059 | 0.75 | RPS6KA5 (0.56) | RPS6KA5RPS6KA4MKNK1MKNK2 | |
| SCHEMBL18803510 | 0.75 | RPS6KA5 (0.67) | RPS6KA5RPS6KA4MKNK1MKNK2 | |
| SCHEMBL16140670 | 0.75 | RPS6KA5 (0.67) | RPS6KA5RPS6KA4MKNK1MKNK2 | |
| SCHEMBL4110930 | 0.73 | MKNK2 (0.45) | MKNK1MKNK2 | |
| SCHEMBL20479193 | 0.72 | MKNK1 (0.58) | RPS6KA5RPS6KA4MKNK1MKNK2 | |
| SCHEMBL18787307 | 0.72 | MKNK2 (0.57) | RPS6KA5RPS6KA4MKNK1MKNK2 | |
| Benzimidazole SCHEMBL28467044 | 0.70 | SMN1; SMN2 (0.45) | — | |
| Benzimidazole SCHEMBL28113801 | 0.70 | SMN1; SMN2 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006038001-A1 | AMINOPYRIMIDINE DERIVATIVES AS JNK INHIBITORS | CELLTECH R & D LIMITED (GB) | 2006-04-13 | — | — | WO | disclosed |