Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA5 | O75582 | 4/20 | 0.56 |
| ▸ | MKNK1 | Q9BUB5 | 12/20 | 0.53 |
| ▸ | MKNK2 | Q9HBH9 | 12/20 | 0.53 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16140386 | 0.86 | RPS6KA5 (0.67) | RPS6KA5MKNK1MKNK2RPS6KA4 | |
| SCHEMBL16140670 | 0.82 | RPS6KA5 (0.67) | RPS6KA5MKNK1MKNK2RPS6KA4HTT | |
| SCHEMBL18803510 | 0.82 | RPS6KA5 (0.67) | RPS6KA5MKNK1MKNK2RPS6KA4HTT | |
| SCHEMBL7501389 | 0.79 | MKNK1 (0.51) | RPS6KA5MKNK1MKNK2HTTFGFR1 | |
| SCHEMBL20479193 | 0.79 | MKNK1 (0.58) | RPS6KA5MKNK1MKNK2RPS6KA4HTT | |
| SCHEMBL18787307 | 0.79 | MKNK2 (0.57) | RPS6KA5MKNK1MKNK2RPS6KA4HTT | |
| Benzimidazole SCHEMBL6039612 | 0.75 | RPS6KA5 (0.53) | RPS6KA5MKNK1MKNK2RPS6KA4 | |
| SCHEMBL25764658 | 0.72 | ALDH1A1 (0.58) | RPS6KA5MKNK1MKNK2HTTFGFR1 | |
| SCHEMBL21554478 | 0.72 | MKNK2 (0.72) | MKNK1MKNK2 | |
| SCHEMBL6039615 | 0.71 | ROCK1 (0.68) | RPS6KA5MKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3564235-A1 | SUBSTITUTED AROMATIC N-HETEROCYCLIC COMPOUNDS AS INHIBITORS OF MITOGEN-ACTIVATED PROTEIN KINASE INTERACTING KINASE 1 (MNK1) AND 2 (MNK2) | Northwestern University (US) | 2019-11-06 | — | — | EP | disclosed |
| US-6716831-B1 | INHIBITION OF FOCAL ADHESION KINASE | ASTRAZENECA AB (SE) | 2004-04-06 | — | — | US | disclosed |
| EP-1161428-B1 | PYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-05-28 | — | — | EP | disclosed |
| EP-1194152-A4 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO INC (US) | 2002-11-06 | — | — | EP | disclosed |
| EP-1194152-A1 | SRC KINASE INHIBITOR COMPOUNDS | Merck & Co., Inc. (US) | 2002-04-10 | — | — | EP | disclosed |
| EP-1161428-A1 | PYRIMIDINE COMPOUNDS | AstraZeneca AB (SE) | 2001-12-12 | — | — | EP | disclosed |
| US-6316444-B1 | SRC kinase inhibitor compounds | MERCK & CO., INC. | 2001-11-13 | — | — | US | disclosed |
| WO-2001000214-A1 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO., INC. (US) | 2001-01-04 | — | — | WO | disclosed |
| WO-2000053595-A1 | PYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2000-09-14 | — | — | WO | disclosed |