Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TSPO | P30536 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20605092 | 0.98 | KDM4E (0.50) | KDM4EMDM2ALDH1A1GAAHTT | |
| SCHEMBL29700458 | 0.92 | KDM4E (0.53) | KDM4EMDM2ALDH1A1GAAHTT | |
| SCHEMBL2649295 | 0.82 | KDM4E (0.46) | KDM4EMDM2ALDH1A1HTTSIGMAR1 | |
| SCHEMBL6765965 | 0.82 | SIGMAR1 (0.61) | KDM4EMDM2ALDH1A1HTTSIGMAR1 | |
| SCHEMBL8259566 | 0.82 | HTR1A (0.55) | KDM4EMDM2ALDH1A1SIGMAR1KMT2A | |
| SCHEMBL792209 | 0.82 | SIGMAR1 (0.49) | ALDH1A1GAAHTTSIGMAR1KMT2A | |
| SCHEMBL2649407 | 0.80 | KDM4E (0.50) | KDM4EMDM2ALDH1A1HTTSIGMAR1 | |
| SCHEMBL11608912 | 0.80 | SIGMAR1 (0.66) | KDM4EMDM2ALDH1A1SIGMAR1KMT2A | |
| SCHEMBL19049402 | 0.80 | KDM4E (0.50) | KDM4EMDM2ALDH1A1SIGMAR1KMT2A | |
| SCHEMBL2650435 | 0.80 | KDM4E (0.50) | KDM4EMDM2ALDH1A1SIGMAR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107698603-B | Thienopyrimidine compound, preparation method thereof, medicinal composition and application thereof | 南京红云生物科技有限公司 | 2022-04-08 | — | — | CN | disclosed |
| CN-107151250-B | Pyrimidine seven-membered ring compound, preparation method thereof, medicinal composition and application thereof | 安徽省新星药物开发有限责任公司 | 2020-03-27 | — | — | CN | disclosed |
| WO-2006038001-A1 | AMINOPYRIMIDINE DERIVATIVES AS JNK INHIBITORS | CELLTECH R & D LIMITED (GB) | 2006-04-13 | — | — | WO | disclosed |