Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 2/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | TOP2A | P11388 | 2/20 | 0.32 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7519249 | 0.80 | CRBN (0.38) | CRBNEPHX2TOP2ATOP2BALDH1A1 | |
| SCHEMBL9827070 | 0.77 | CRBN (0.40) | CRBNEPHX2TOP2ATOP2BALDH1A1 | |
| SCHEMBL8445095 | 0.77 | CRBN (0.35) | CRBNEPHX2 | |
| SCHEMBL8999579 | 0.75 | CRBN (0.46) | CRBNEPHX2TOP2ATOP2BALDH1A1 | |
| SCHEMBL2411663 | 0.75 | CRBN (0.34) | CRBN | |
| SCHEMBL5235519 | 0.71 | — | — | |
| SCHEMBL561442 | 0.71 | — | — | |
| SCHEMBL22114487 | 0.71 | — | — | |
| SCHEMBL191785 | 0.71 | — | — | |
| SCHEMBL9064412 | 0.71 | CRBN (0.38) | CRBNEPHX2TOP2ATOP2BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006038001-A1 | AMINOPYRIMIDINE DERIVATIVES AS JNK INHIBITORS | CELLTECH R & D LIMITED (GB) | 2006-04-13 | — | — | WO | disclosed |