Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 2/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | TOP2A | P11388 | 1/20 | 0.31 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6039701 | 0.80 | CRBN (0.39) | CRBNEPHX2TOP2ATOP2BALDH1A1 | |
| SCHEMBL8445095 | 0.75 | CRBN (0.35) | CRBNEPHX2 | |
| SCHEMBL9827070 | 0.75 | CRBN (0.40) | CRBNEPHX2TOP2ATOP2BALDH1A1 | |
| SCHEMBL8999579 | 0.74 | CRBN (0.46) | CRBNEPHX2TOP2ATOP2BALDH1A1 | |
| SCHEMBL2411663 | 0.74 | CRBN (0.34) | CRBN | |
| SCHEMBL24356068 | 0.72 | LMNA (0.34) | — | |
| SCHEMBL24356067 | 0.72 | LMNA (0.34) | — | |
| SCHEMBL561442 | 0.70 | — | — | |
| SCHEMBL22114487 | 0.70 | — | — | |
| SCHEMBL191785 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 59 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1446805-A | Method for preparing 1-proparagyl hydantoin | KAIDA FINE CHEMICAL INDUSTRY C (CN) | 2003-10-08 | — | — | CN | claimed |
| EP-0560622-B1 | A process for producing 1-propargylimidazolidine-2,4-dione | SUMITOMO CHEMICAL CO (JP) | 2000-08-23 | — | — | EP | claimed |
| EP-0560581-B1 | Process for producing 3-hydroxymethyl-1-propargyl-imidazolidine-2,4-dione | SUMITOMO CHEMICAL CO (JP) | 2000-06-07 | — | — | EP | claimed |
| US-5350859-A | Process for producing 3-hydroxymethyl-1-propargylimidazolidine-2,4-dione | SUMOTOMO CHEMICAL COMPANY, LTD. (JP) | 1994-09-27 | — | — | US | claimed |
| EP-0560622-A2 | A process for producing 1-propargylimidazolidine-2,4-dione | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1993-09-15 | — | — | EP | claimed |
| EP-0560581-A2 | Process for producing 3-hydroxymethyl-1-propargyl-imidazolidine-2,4-dione | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1993-09-15 | — | — | EP | claimed |
| EP-0285270-B1 | A METHOD FOR PRODUCING 1-PROPARGYL-2,4-DIOXOIMIDAZOLIDINE | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1992-06-03 | — | — | EP | claimed |
| EP-0285270-A1 | A method for producing 1-propargyl-2,4-dioxoimidazolidine | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1988-10-05 | — | — | EP | claimed |
| JP-5255271-A | — | — | None | — | — | JP | disclosed |
| CN-222196199-U | Impurity filtering device for producing 5, 5-dimethyl hydantoin | 河北利仕化学科技有限公司 | 2024-12-20 | — | — | CN | disclosed |
| US-20220142157-A1 | ARTHROPOD CONTROLLING COMPOSITION | FIRMENICH SA (CH) | 2022-05-12 | — | — | US | disclosed |
| CN-114344978-A | Filtering device applied to synthesized 5, 5-dimethylhydantoin | 河北利仕化学科技有限公司 | 2022-04-15 | — | — | CN | disclosed |
| US-20180016275-A1 | NOVEL DIHYDROPYRIMIDINOISOQUINOLINONES AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS (GPR84 ANTAGONISTS) | GALAPAGOS NV (BE) | 2018-01-18 | — | — | US | disclosed |
| CN-104870445-B | New dihydro-pyrimidin and isobioquin group and its pharmaceutical composition (GPR84 antagonists) for treating inflammatory disease | 加拉帕戈斯股份有限公司 | 2017-09-15 | — | — | CN | disclosed |
| US-4827020-A | Propargyl amide precursor to 1-propargyl-2,4-dioxoimidazolidine | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1989-05-02 | — | — | US | disclosed |
| US-4827020-A | Propargyl amide precursor to 1-propargyl-2,4-dioxoimidazolidine | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1989-05-02 | — | — | US | disclosed |
| US-4827020-A | Propargyl amide precursor to 1-propargyl-2,4-dioxoimidazolidine | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1989-05-02 | — | — | US | disclosed |
| EP-0285270-A1 | A method for producing 1-propargyl-2,4-dioxoimidazolidine | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1988-10-05 | — | — | EP | disclosed |
| EP-0285270-A1 | A method for producing 1-propargyl-2,4-dioxoimidazolidine | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1988-10-05 | — | — | EP | disclosed |
| EP-0285270-A1 | A method for producing 1-propargyl-2,4-dioxoimidazolidine | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1988-10-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180016275-A1 | NOVEL DIHYDROPYRIMIDINOISOQUINOLINONES AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS (GPR84 ANTAGONISTS) | GPR84, GPR88, GPR65 | CRBN 4060/4885EPHX2 2505/4885TOP2A 4522/4885 |
| US-20220142157-A1 | ARTHROPOD CONTROLLING COMPOSITION | AGO2, NOP2, FBL | CRBN 2092/4885EPHX2 1349/4885TOP2A 3255/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.