Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 5/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ADH1B | P00325 | 1/20 | 0.33 |
| ▸ | ADH1C | P00326 | 1/20 | 0.33 |
| ▸ | ADH1A | P07327 | 1/20 | 0.33 |
| ▸ | ADH4 | P08319 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22953693 | 0.73 | ALDH1A1 (0.60) | ALDH1A1HSD17B10SIGMAR1EPHX2EPHX1 | |
| SCHEMBL22781855 | 0.73 | ALDH1A1 (0.60) | ALDH1A1HSD17B10SIGMAR1EPHX2EPHX1 | |
| SCHEMBL22182237 | 0.73 | ALDH1A1 (0.60) | ALDH1A1HSD17B10SIGMAR1EPHX2EPHX1 | |
| SCHEMBL25112316 | 0.73 | ALDH1A1 (0.60) | ALDH1A1HSD17B10SIGMAR1EPHX2EPHX1 | |
| SCHEMBL22903324 | 0.73 | ALDH1A1 (0.60) | ALDH1A1HSD17B10SIGMAR1EPHX2EPHX1 | |
| SCHEMBL23718695 | 0.73 | ALDH1A1 (0.60) | ALDH1A1HSD17B10SIGMAR1EPHX2EPHX1 | |
| SCHEMBL24664035 | 0.73 | ALDH1A1 (0.60) | ALDH1A1HSD17B10SIGMAR1EPHX2EPHX1 | |
| SCHEMBL24950242 | 0.73 | ALDH1A1 (0.60) | ALDH1A1HSD17B10SIGMAR1EPHX2EPHX1 | |
| SCHEMBL21265952 | 0.73 | ALDH1A1 (0.60) | ALDH1A1HSD17B10SIGMAR1EPHX2EPHX1 | |
| SCHEMBL21509890 | 0.73 | ALDH1A1 (0.60) | ALDH1A1HSD17B10SIGMAR1EPHX2EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060014790-A1 | Methods of treatment of amyloidosis using spirocyclohexane aspartyl-protease inhibitors | ELAN PHARMACEUTICALS, INC. | 2006-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060014790-A1 | Methods of treatment of amyloidosis using spirocyclohexane aspartyl-protease inhibitors | ASPH, DNPEP, ACE | ALDH1A1 393/4885HSD17B10 265/4885NPSR1 2940/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.