Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Phenanthroline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.70 |
| ▸ | LMNA | P02545 | 4/20 | 0.70 |
| ▸ | MAPT | P10636 | 4/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.70 |
| ▸ | HTT | P42858 | 3/20 | 0.70 |
| ▸ | CCR1 | P32246 | 3/20 | 0.70 |
| ▸ | CCR5 | P51681 | 3/20 | 0.70 |
| ▸ | CCR8 | P51685 | 3/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.70 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.70 |
| ▸ | MMP2 | P08253 | 2/20 | 0.70 |
| ▸ | TSHR | P16473 | 2/20 | 0.70 |
| ▸ | GMNN | O75496 | 1/20 | 0.70 |
| ▸ | TP53 | P04637 | 1/20 | 0.70 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.70 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.70 |
| ▸ | MMP9 | P14780 | 1/20 | 0.70 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.70 |
| ▸ | MMP8 | P22894 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenanthroline SCHEMBL8686399 | 1.00 | KDM4E (0.70) | KDM4ELMNAMAPTTDP1HTT | |
| Phenanthroline SCHEMBL30613730 | 0.96 | KDM4E (0.70) | KDM4ELMNAMAPTTDP1HTT | |
| Phenanthroline SCHEMBL8722750 | 0.96 | KDM4E (0.70) | KDM4ELMNAMAPTTDP1HTT | |
| Phenanthroline SCHEMBL623252 | 0.96 | KDM4E (0.70) | KDM4ELMNAMAPTTDP1HTT | |
| Phenanthroline SCHEMBL29278209 | 0.96 | KDM4E (0.70) | KDM4ELMNAMAPTTDP1HTT | |
| Phenanthroline SCHEMBL2210775 | 0.96 | KDM4E (0.70) | KDM4ELMNAMAPTTDP1HTT | |
| Phenanthroline SCHEMBL5888427 | 0.94 | KDM4E (0.67) | KDM4ELMNAMAPTTDP1HTT | |
| Phenanthroline SCHEMBL1730256 | 0.86 | CCR1 (0.94) | KDM4ELMNAMAPTTDP1HTT | |
| Phenanthroline SCHEMBL31300436 | 0.86 | CCR1 (0.94) | KDM4ELMNAMAPTTDP1HTT | |
| Phenanthroline SCHEMBL5465049 | 0.86 | CCR1 (0.94) | KDM4ELMNAMAPTTDP1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-3545399-B2 | — | — | 2004-07-21 | — | — | JP | claimed |
| EP-0646180-A4 | METHODS FOR INACTIVATING NUCLEOTIDE SEQUENCES AND METAL CHELATES FOR USE THEREIN. | ABBOTT LAB (US) | 1998-03-11 | — | — | EP | claimed |
| EP-0646180-A1 | METHODS FOR INACTIVATING NUCLEOTIDE SEQUENCES AND METAL CHELATES FOR USE THEREIN | ABBOTT LABORATORIES (US) | 1995-04-05 | — | — | EP | claimed |
| WO-1993020241-A1 | METHODS FOR INACTIVATING NUCLEOTIDE SEQUENCES AND METAL CHELATES FOR USE THEREIN | ABBOTT LABORATORIES (US) | 1993-10-14 | — | — | WO | claimed |
| US-20060068430-A1 | Purification of biomolecules from contaminating intact nucleic acids | SIGMA-ALDRICH CO. | 2006-03-30 | — | — | US | disclosed |
| EP-0646180-B1 | METHODS FOR INACTIVATING NUCLEOTIDE SEQUENCES AND METAL CHELATES FOR USE THEREIN | ABBOTT LAB (US) | 2002-02-27 | — | — | EP | disclosed |
| US-5858650-A | BLOCKING POLYMERASE, LIPASE CHAIN REACTION | ABBOTT LABORATORIES (US) | 1999-01-12 | — | — | US | disclosed |