Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 6/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | CCR2 | P41597 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6045354 | 0.96 | MCL1 (0.42) | MCL1HPGDSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL195742 | 0.88 | ALDH1A1 (0.48) | MCL1HPGDSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL9811800 | 0.82 | BRD4 (0.43) | MCL1HPGDSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL2977751 | 0.77 | KMT2A (0.47) | MCL1HPGDSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL2974317 | 0.74 | ALDH1A1 (0.43) | HPGDSMN1; SMN2LMNAALDH1A1KDM4E | |
| SCHEMBL9040161 | 0.73 | ALDH1A1 (0.61) | MCL1HPGDALDH1A1KDM4EKMT2A | |
| SCHEMBL1627597 | 0.71 | ALDH1A1 (0.45) | HPGDSMN1; SMN2ALDH1A1KDM4EGAA | |
| SCHEMBL4101677 | 0.69 | CA12 (0.50) | ALDH1A1MEN1TSHRKMT2ABRD4 | |
| SCHEMBL6755386 | 0.68 | CCR2 (0.66) | MCL1ALDH1A1CCR2TSHRL3MBTL1 | |
| SCHEMBL195008 | 0.68 | ALDH1A1 (0.49) | HPGDSMN1; SMN2ALDH1A1KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060241108-A1 | Substituted phenoxazines and acridones as inhibitors of AKT | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2006-10-26 | — | — | US | claimed |
| WO-2006094207-A2 | SUBSTITUTED PHENOXAZINES AND ACRIDONES AS INHIBITORS OF AKT | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2006-09-08 | — | — | WO | claimed |
| US-20060241108-A1 | Substituted phenoxazines and acridones as inhibitors of AKT | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2006-10-26 | — | — | US | disclosed |
| WO-2006094207-A2 | SUBSTITUTED PHENOXAZINES AND ACRIDONES AS INHIBITORS OF AKT | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2006-09-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060241108-A1 | Substituted phenoxazines and acridones as inhibitors of AKT | AKT1S1, AKT3, PIK3CA | MCL1 1182/4885HPGD 3878/4885SMN1; SMN2 4481/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.