Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 13/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 9/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6045551 | 0.98 | OPRM1 (0.43) | KDM4EALDH1A1OPRM1SIGMAR1KCNH2 | |
| Oxalic Acid SCHEMBL6045490 | 0.93 | OPRM1 (0.46) | OPRM1SIGMAR1KCNH2ACHEOPRD1 | |
| Oxalic Acid SCHEMBL6045448 | 0.92 | OPRM1 (0.41) | KDM4EALDH1A1OPRM1SIGMAR1KCNH2 | |
| Oxalic Acid SCHEMBL6045606 | 0.91 | ALDH1A1 (0.43) | KDM4EALDH1A1CHRM2CHRM3ACHE | |
| SCHEMBL6045648 | 0.91 | OPRM1 (0.47) | OPRM1SIGMAR1KCNH2ACHEOPRD1 | |
| SCHEMBL6045495 | 0.91 | OPRM1 (0.42) | ALDH1A1OPRM1SIGMAR1KCNH2CHRM2 | |
| SCHEMBL6045562 | 0.90 | CHRM2 (0.43) | KDM4EALDH1A1CHRM2CHRM3ACHE | |
| SCHEMBL6045547 | 0.89 | OPRM1 (0.44) | OPRM1SIGMAR1KCNH2ACHEOPRD1 | |
| SCHEMBL6045610 | 0.88 | CHRM2 (0.39) | KDM4EALDH1A1OPRM1SIGMAR1CHRM2 | |
| Oxalic Acid SCHEMBL6045777 | 0.88 | ALDH1A1 (0.43) | KDM4EALDH1A1OPRM1SIGMAR1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060252797-A1 | Receptor regulator | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-11-09 | — | — | US | disclosed |
| EP-1559428-A1 | RECEPTOR REGULATOR | Takeda Pharmaceutical Company Limited (JP) | 2005-08-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060252797-A1 | Receptor regulator | NMUR1, NMUR2, NMBR | OPRM1 148/4885KDM4E 3254/4885ALDH1A1 4220/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.