Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 16/20 | 1.00 |
| ▸ | MMP9 | P14780 | 18/20 | 0.80 |
| ▸ | MMP1 | P03956 | 11/20 | 0.80 |
| ▸ | MMP8 | P22894 | 6/20 | 0.75 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.66 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6046021 | 1.00 | MMP2 (1.00) | MMP2MMP9MMP1MMP8ADAMTS4 | |
| SCHEMBL6046084 | 0.89 | MMP9 (1.00) | MMP2MMP9MMP1MMP8ADAMTS4 | |
| SCHEMBL6046150 | 0.89 | MMP9 (1.00) | MMP2MMP9MMP1MMP8ADAMTS4 | |
| SCHEMBL6046156 | 0.89 | MMP9 (1.00) | MMP2MMP9MMP1MMP8ADAMTS4 | |
| SCHEMBL6046092 | 0.89 | MMP9 (1.00) | MMP2MMP9MMP1MMP8ADAMTS4 | |
| SCHEMBL6046094 | 0.89 | MMP9 (1.00) | MMP2MMP9MMP1MMP8ADAMTS4 | |
| SCHEMBL6046088 | 0.89 | MMP9 (1.00) | MMP2MMP9MMP1MMP8ADAMTS4 | |
| SCHEMBL6046105 | 0.88 | MMP9 (1.00) | MMP2MMP9MMP1MMP8ADAMTS4 | |
| SCHEMBL6046100 | 0.88 | MMP9 (1.00) | MMP2MMP9MMP1MMP8ADAMTS4 | |
| SCHEMBL6045992 | 0.87 | MMP9 (0.77) | MMP2MMP9MMP1MMP8ADAMTS4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6576664-B1 | 1-amido-2-hydroxy-substituted-indanes; suppressing production of tumor necrosis factor | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2003-06-10 | — | — | US | claimed |
| US-20060281699-A1 | Methods, compositions and compound assays for inhibiting amyloid-beta protein production | MERCHIERS PASCAL G | 2006-12-14 | — | — | US | disclosed |