Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.38 |
| ▸ | CDK7 | P50613 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | CCNH | P51946 | 1/20 | 0.38 |
| ▸ | POLA1 | P09884 | 1/20 | 0.33 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.31 |
| ▸ | MAP3K6 | O95382 | 1/20 | 0.31 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.31 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.31 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | PARP1 | P09874 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1721311 | 0.82 | ALDH1A1 (0.55) | ALDH1A1KDM4ERXFP1CDK2PAK1 | |
| SCHEMBL788098 | 0.76 | ALDH1A1 (0.52) | ALDH1A1KDM4ERXFP1CDK2PAK1 | |
| SCHEMBL30075070 | 0.76 | ALDH1A1 (0.52) | ALDH1A1KDM4ERXFP1CDK2PAK1 | |
| SCHEMBL30556758 | 0.75 | ALDH1A1 (0.50) | ALDH1A1KDM4ERXFP1CDK2PAK1 | |
| SCHEMBL29599053 | 0.75 | RXFP1 (0.51) | ALDH1A1KDM4ERXFP1CDK2PAK1 | |
| SCHEMBL7771676 | 0.75 | ALDH1A1 (0.50) | ALDH1A1KDM4ERXFP1CDK2PAK1 | |
| SCHEMBL28190667 | 0.72 | ALDH1A1 (0.47) | ALDH1A1KDM4ERXFP1CDK2PAK1 | |
| SCHEMBL6046332 | 0.71 | KDM4E (0.31) | ALDH1A1KDM4E | |
| SCHEMBL28486689 | 0.71 | ALDH1A1 (0.46) | ALDH1A1KDM4ERXFP1CDK2PAK1 | |
| SCHEMBL29400266 | 0.71 | KDM4E (0.46) | ALDH1A1KDM4ERXFP1CDK2PAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4161519-A1 | PURINES AND METHODS OF THEIR USE | Yumanity Therapeutics, Inc. (US) | 2023-04-12 | — | — | EP | disclosed |
| EP-2953470-A1 | 2,6,7 SUBSTITUTED PURINES AS HDM2 INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2015-12-16 | — | — | EP | disclosed |
| WO-2014123882-A1 | 2,6,7 SUBSTITUTED PURINES AS HDM2 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2014-08-14 | — | — | WO | disclosed |
| US-20060199198-A1 | Polymorphic DNA fragments and uses thereof | SOLEXA, INC., | 2006-09-07 | — | — | US | disclosed |