Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.82 |
| ▸ | KDR | P35968 | 16/20 | 0.58 |
| ▸ | RET | P07949 | 12/20 | 0.58 |
| ▸ | KIF5B | P33176 | 11/20 | 0.58 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.56 |
| ▸ | FLT1 | P17948 | 3/20 | 0.56 |
| ▸ | FLT4 | P35916 | 3/20 | 0.56 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.56 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.56 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.56 |
| ▸ | AURKA | O14965 | 1/20 | 0.54 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.54 |
| ▸ | INSR | P06213 | 1/20 | 0.54 |
| ▸ | FBP1 | P09467 | 1/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.54 |
| ▸ | CLK1 | P49759 | 1/20 | 0.54 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.54 |
| ▸ | TEK | Q02763 | 1/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.54 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6046871 | 0.85 | EGFR (0.62) | EGFRKDRRETKIF5BFGFR1 | |
| SCHEMBL3958826 | 0.83 | EGFR (0.62) | EGFRKDRRETKIF5BFGFR1 | |
| SCHEMBL14515606 | 0.81 | KDR (0.72) | EGFRKDRRETKIF5BFLT1 | |
| SCHEMBL30124192 | 0.81 | EGFR (0.83) | EGFRKDRRETKIF5BFLT4 | |
| SCHEMBL29679736 | 0.81 | EGFR (0.83) | EGFRKDRRETKIF5BFLT4 | |
| SCHEMBL8383 | 0.81 | EGFR (0.83) | EGFRKDRRETKIF5BFLT4 | |
| SCHEMBL17179538 | 0.80 | EGFR (0.70) | EGFRKDRRETKIF5BFGFR1 | |
| SCHEMBL16075710 | 0.80 | EGFR (0.70) | EGFRKDRRETKIF5BFGFR1 | |
| SCHEMBL202827 | 0.80 | EGFR (0.73) | EGFRKDRRETKIF5BFLT1 | |
| SCHEMBL14843536 | 0.80 | EGFR (0.70) | EGFRKDRRETKIF5BFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633365-A1 | MACROCYCLIC QUINAZOLINE DERIVATIVES AS ANTIPROLIFERATIVE AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-03-15 | — | — | EP | disclosed |
| WO-2004105765-A1 | MACROCYCLIC QUINAZOLINE DERIVATIVES AS ANTIPROLIFERATIVE AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2004-12-09 | — | — | WO | disclosed |