SCHEMBL6046942

SCHEMBL6046942

COc1ccc(C(=O)c2nc(N)c3ncn(C=C=O)c3n2)cc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE8B O95263 1/20 0.40
KMT2A Q03164 7/20 0.38
PI4KA P42356 1/20 0.37
PI4K2B Q8TCG2 1/20 0.37
PI4K2A Q9BTU6 1/20 0.37
PI4KB Q9UBF8 1/20 0.37
MEN1 O00255 4/20 0.37
NPC1 O15118 4/20 0.37
CCNA2 P20248 1/20 0.36
CDK2 P24941 1/20 0.36
CHKA P35790 1/20 0.36
ALDH1A1 P00352 1/20 0.36
KLK7 P49862 1/20 0.36
KLK14 Q9P0G3 1/20 0.36
KLK5 Q9Y337 1/20 0.36
CDK5 Q00535 3/20 0.35
CDK5R1 Q15078 3/20 0.35
LMNA P02545 2/20 0.35
CHRM4 P08173 1/20 0.35
MAPT P10636 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7640806 0.69 KMT2A (0.44) KMT2AMEN1NPC1CCNA2CDK2
SCHEMBL17868331 0.68 RXFP1 (0.48) KMT2AMEN1NPC1CCNA2CDK2
SCHEMBL6046937 0.65 BRD4 (0.48) KMT2AMEN1NPC1CDK2CDK5
SCHEMBL6046938 0.63 PI4KA (0.59) KMT2API4KAPI4K2BPI4K2API4KB
SCHEMBL51509 0.60 RXFP1 (0.79) KMT2AMEN1NPC1ALDH1A1LMNA
SCHEMBL9418310 0.60 RXFP1 (0.79) KMT2AMEN1NPC1ALDH1A1LMNA
SCHEMBL17868339 0.60 NPC1 (0.55) KMT2AMEN1NPC1ALDH1A1LMNA
SCHEMBL5141691 0.59 MAPK1 (0.67) KMT2AMEN1NPC1ALDH1A1LMNA
SCHEMBL1872764 0.59 MAPK1 (0.67) KMT2AMEN1NPC1ALDH1A1LMNA
SCHEMBL13638606 0.59 MEN1 (0.67) KMT2AMEN1NPC1CCNA2CDK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1105525-B1 A PROCESS FOR PREPARING PEPTIDE NUCLEIC ACID PROBE USING POLYMERIC PHOTOACID GENERATOR SAMSUNG ELECTRONICS CO LTD (KR) 2006-11-02 EP disclosed
US-6660479-B2 Derivatizing surface of a solid matrix and attaching linker with acid- labile protecting group on solid matrix; coating solid matrix with polymeric photoacid generator(PAG); exposing solid matrix thus coated to light to generate acid; reacting SAMSUNG ELECTRONICS CO., LTD. (KR) 2003-12-09 US disclosed
EP-1105525-A4 A PROCESS FOR PREPARING PEPTIDE NUCLEIC ACID PROBE USING POLYMERIC PHOTOACID GENERATOR SAMSUNG ELECTRONICS CO LTD (KR) 2003-07-30 EP disclosed
US-20020122874-A1 Process for preparing peptide nucleic acid probe using polymeric photoacid generator SAMSUNG ELECTRONICS CO., LTD. (KR) 2002-09-05 US disclosed
US-6359125-B1 DERIVATIZING SURFACE OF SOLID MATRIX WITH AMINOALKYLOXYSILANE AND ATTACHING LINKER WITH ACID-LABILE PROTECTING GROUP TO AMINE GROUP ON MATRIX, COATING MATRIX WITH POLYMERIC PHOTOACID GENERATOR, EXPOSING TO LIGHT, ATTACHING PEPTIDE NUCLEIC ACID SAMSUNG ELECTRONICS CO., LTD. (KR) 2002-03-19 US disclosed
EP-1105525-A1 A PROCESS FOR PREPARING PEPTIDE NUCLEIC ACID PROBE USING POLYMERIC PHOTOACID GENERATOR SAMSUNG ELECTRONICS CO., LTD. (KR) 2001-06-13 EP disclosed
WO-2000075372-A1 A PROCESS FOR PREPARING PEPTIDE NUCLEIC ACID PROBE USING POLYMERIC PHOTOACID GENERATOR SAMSUNG ELECTRONICS CO., LTD. (KR) 2000-12-14 WO disclosed