SCHEMBL6047459

SCHEMBL6047459

NC(CCCNC1CCCc2cccnc21)Cc1ncc[nH]1

nearest known ligand 0.41

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 2/20 0.41
HDAC6 Q9UBN7 2/20 0.41
CXCR4 P61073 17/20 0.39
CYP2D6 P10635 3/20 0.38
CHRM2 P08172 1/20 0.38
DRD2 P14416 1/20 0.38
OPRM1 P35372 1/20 0.38
KCNH2 Q12809 1/20 0.38
CYP3A4 P08684 1/20 0.36
SLC40A1 Q9NP59 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4761081 0.85 HDAC1 (0.39) HDAC1HDAC6CXCR4CYP2D6CHRM2
SCHEMBL4759592 0.85 CXCR4 (0.52) CXCR4CYP2D6CHRM2DRD2OPRM1
SCHEMBL5112746 0.85 CXCR4 (0.52) CXCR4CYP2D6CHRM2DRD2OPRM1
SCHEMBL5103871 0.85 CXCR4 (0.52) CXCR4CYP2D6CHRM2DRD2OPRM1
SCHEMBL30834051 0.85 CXCR4 (0.52) CXCR4CYP2D6CHRM2DRD2OPRM1
SCHEMBL4711584 0.82 HDAC1 (0.47) HDAC1HDAC6CXCR4CYP2D6CHRM2
SCHEMBL5057520 0.82 HDAC1 (0.46) HDAC1HDAC6CXCR4CYP2D6OPRM1
SCHEMBL5106535 0.81 CXCR4 (0.48) HDAC1HDAC6CXCR4CYP2D6CHRM2
SCHEMBL4932583 0.81 HDAC1 (0.56) HDAC1HDAC6CXCR4CYP2D6CHRM2
SCHEMBL7074356 0.80 CXCR4 (0.40) HDAC1HDAC6CXCR4CYP2D6CHRM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1628533-A2 CHEMOKINE RECEPTOR BINDING HETEROCYCLIC COMPOUNDS WITH ENHANCED EFFICACY ANORMED INC. (CA) 2006-03-01 EP disclosed
WO-2004106493-A2 CHEMOKINE RECEPTOR BINDING HETEROCYCLIC COMPOUNDS WITH ENHANCED EFFICACY ANORMED INC. (CA) 2004-12-09 WO disclosed