Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | PLAU | P00749 | 2/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | PLG | P00747 | 1/20 | 0.40 |
| ▸ | PLAT | P00750 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6047578 | 0.85 | CYP1A1 (0.42) | ALDH1A1MAOB | |
| SCHEMBL6047634 | 0.83 | CYP1A1 (0.40) | KMT2AMAOB | |
| SCHEMBL6047612 | 0.82 | MAOB (0.40) | MAPTMEN1KMT2AALDH1A1NPSR1 | |
| SCHEMBL6047630 | 0.81 | CYP3A4 (0.39) | ALDH1A1MAOB | |
| SCHEMBL6047641 | 0.76 | ALKBH3 (0.34) | MAPTMEN1KMT2AALDH1A1NPSR1 | |
| SCHEMBL6047590 | 0.75 | MEN1 (0.41) | MAPTMEN1KMT2AALDH1A1PKM | |
| SCHEMBL6047654 | 0.74 | NUDT1 (0.42) | MAPTMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL28920300 | 0.73 | NFE2L2 (0.51) | MAPTMEN1KMT2AALDH1A1PKM | |
| SCHEMBL30009634 | 0.73 | NFE2L2 (0.51) | MAPTMEN1KMT2AALDH1A1PKM | |
| SCHEMBL6047586 | 0.73 | CHRNA7 (0.35) | MAPTMEN1KMT2ANPSR1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2006501194-A | — | — | 2006-01-12 | — | — | JP | claimed |
| EP-1525190-A1 | CCK-1 RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-04-27 | — | — | EP | claimed |
| WO-2004007463-A1 | CCK-1 RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2004-01-22 | — | — | WO | claimed |