Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 3/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.38 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.38 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | GALR1 | P47211 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6047625 | 0.83 | HTR2C (0.35) | HTR2CNOTUMTSHRHTR1AHTR7 | |
| SCHEMBL1263144 | 0.71 | TSHR (0.58) | HTR2CKDM1AKIF11NOTUMIDO1 | |
| SCHEMBL29678302 | 0.71 | TSHR (0.58) | HTR2CKDM1AKIF11NOTUMIDO1 | |
| SCHEMBL17135818 | 0.70 | HTR2C (0.43) | HTR2CKDM1AKIF11NOTUMIDO1 | |
| Ammonia Solution, Strong SCHEMBL20472961 | 0.69 | MAOB (0.56) | HTR2CKDM1AKIF11NOTUMIDO1 | |
| SCHEMBL27895569 | 0.68 | HTR2C (0.44) | HTR2CKDM1AKIF11NOTUMIDO1 | |
| SCHEMBL6047584 | 0.68 | MAPT (0.42) | HTR2CKDM1ANOTUMIDO1ADORA2A | |
| SCHEMBL1065756 | 0.66 | HTR2C (0.53) | HTR2CKDM1ANOTUMIDO1ASIC3 | |
| SCHEMBL1538783 | 0.66 | MAOB (0.50) | HTR2CKDM1AKIF11NOTUMIDO1 | |
| SCHEMBL29420699 | 0.66 | KIF11 (0.62) | KDM1AKIF11NOTUMIDO1ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2006501194-A | — | — | 2006-01-12 | — | — | JP | claimed |
| EP-1525190-A1 | CCK-1 RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-04-27 | — | — | EP | claimed |
| WO-2004007463-A1 | CCK-1 RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2004-01-22 | — | — | WO | claimed |