Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | KCNA5 | P22460 | 4/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.34 |
| ▸ | MAPT | P10636 | 5/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 4/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HPGDS | O60760 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.32 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1384138 | 0.81 | RAB9A (0.55) | RAB9ANPC1KCNA5KCNH2ALDH1A1 | |
| SCHEMBL6047753 | 0.78 | PDE4B (0.38) | RAB9ANPC1PDE4BKCNA5KCNH2 | |
| SCHEMBL1384577 | 0.72 | KCNA5 (0.59) | RAB9ANPC1KCNA5KCNH2ALDH1A1 | |
| SCHEMBL1384722 | 0.70 | KCNA5 (0.57) | RAB9ANPC1PDE4BKCNA5KCNH2 | |
| SCHEMBL1378608 | 0.70 | KCNA5 (0.54) | RAB9ANPC1KCNA5KCNH2ALDH1A1 | |
| SCHEMBL9940416 | 0.65 | KDM4E (0.40) | ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL1382839 | 0.64 | KDM4E (0.45) | RAB9ANPC1KCNA5KCNH2ALDH1A1 | |
| SCHEMBL3115869 | 0.64 | KCNA5 (0.58) | RAB9ANPC1PDE4BKCNA5KCNH2 | |
| SCHEMBL2167818 | 0.62 | KCNA5 (0.43) | KCNA5KCNH2ALDH1A1MAPTKDM4E | |
| SCHEMBL149899 | 0.61 | MAPK1 (0.56) | RAB9ANPC1ALDH1A1HSD17B10MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060276450-A1 | Isoquinoline potassium channel inhibitors | MERCK SHARP & DOHME CORP. | 2006-12-07 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060276450-A1 | Isoquinoline potassium channel inhibitors | KCNQ1, KCNQ2, KCNJ2 | RAB9A 2350/4885NPC1 484/4885PDE4B 1421/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.