Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.39 |
| ▸ | GCK | P35557 | 4/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.38 |
| ▸ | PPIB | P23284 | 1/20 | 0.37 |
| ▸ | PPID | Q08752 | 1/20 | 0.37 |
| ▸ | PPIG | Q13427 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7168397 | 0.89 | HSP90AA1 (0.41) | HSP90AA1HSP90AB1RIPK1GCKHCRTR1 | |
| SCHEMBL6049177 | 0.83 | HSP90AA1 (0.41) | HSP90AA1HSP90AB1RIPK1GCKHCRTR1 | |
| SCHEMBL23064471 | 0.71 | PPID (0.48) | HSP90AA1HSP90AB1RIPK1PPIBPPID | |
| SCHEMBL28537451 | 0.71 | PPID (0.48) | HSP90AA1HSP90AB1RIPK1PPIBPPID | |
| SCHEMBL28535098 | 0.69 | RIPK1 (0.46) | HSP90AA1HSP90AB1RIPK1HSD11B1 | |
| SCHEMBL28535096 | 0.69 | RIPK1 (0.46) | HSP90AA1HSP90AB1RIPK1HSD11B1 | |
| SCHEMBL2645563 | 0.69 | GCK (0.44) | RIPK1GCKHSD11B1 | |
| SCHEMBL31525016 | 0.68 | RIPK1 (0.45) | HSP90AA1HSP90AB1RIPK1 | |
| SCHEMBL1576663 | 0.68 | RIPK1 (0.73) | HSP90AA1HSP90AB1RIPK1HSD11B1 | |
| SCHEMBL11511479 | 0.67 | FFAR1 (0.45) | HSP90AA1HSP90AB1FFAR1PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1184372-B1 | Phenoxyphenylheterocycle derivatives as selective serotonin reuptake inhibitors (SSRIs) | PFIZER LTD (GB) | 2006-04-26 | — | — | EP | disclosed |