Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | GCK | P35557 | 3/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.37 |
| ▸ | PPIB | P23284 | 1/20 | 0.37 |
| ▸ | PPID | Q08752 | 1/20 | 0.37 |
| ▸ | PPIG | Q13427 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6049323 | 0.89 | HSP90AA1 (0.40) | HSP90AA1HSP90AB1RIPK1GCKHCRTR1 | |
| SCHEMBL6049177 | 0.86 | HSP90AA1 (0.41) | HSP90AA1HSP90AB1RIPK1MAPTGCK | |
| Hydrochloric Acid SCHEMBL6049195 | 0.78 | SLC6A4 (0.45) | SLC6A4MAPTSLC6A2SLC6A3HTR2A | |
| SCHEMBL23064471 | 0.73 | PPID (0.48) | HSP90AA1HSP90AB1RIPK1PPIBPPID | |
| SCHEMBL28537451 | 0.73 | PPID (0.48) | HSP90AA1HSP90AB1RIPK1PPIBPPID | |
| SCHEMBL28535096 | 0.71 | RIPK1 (0.46) | HSP90AA1HSP90AB1RIPK1HSD11B1 | |
| SCHEMBL28535098 | 0.71 | RIPK1 (0.46) | HSP90AA1HSP90AB1RIPK1HSD11B1 | |
| SCHEMBL2645563 | 0.71 | GCK (0.44) | RIPK1SLC6A4GCKHSD11B1 | |
| SCHEMBL31525016 | 0.70 | RIPK1 (0.45) | HSP90AA1HSP90AB1RIPK1 | |
| SCHEMBL1576663 | 0.70 | RIPK1 (0.73) | HSP90AA1HSP90AB1RIPK1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6630504-B2 | Activity as selective serotonin re- uptake inhibitors (SSRIs); for therapy and prophylaxis of depression, attention deficit hyperactivity disorder, obsessive-compulsive disorder, post-traumatic stress disorder, sexual dysfunction | PFIZER INC. | 2003-10-07 | — | — | US | disclosed |
| US-20020183303-A1 | Phenoxyphenylheterocyclyl derivatives as SSRIs | PFIZER INC. | 2002-12-05 | — | — | US | disclosed |
| EP-1184372-A1 | Phenoxyphenylheterocycle derivatives as selective serotonin reuptake inhibitors (SSRIs) | Pfizer Limited (GB) | 2002-03-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020183303-A1 | Phenoxyphenylheterocyclyl derivatives as SSRIs | CRHR1, NR3C1, HTR6 | HSP90AA1 2431/4885HSP90AB1 2039/4885RIPK1 4610/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.