Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.55 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.52 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6458967 | 0.93 | PTGER4 (0.54) | MAPK8PTGER4LMNAHPGDSMN1; SMN2 | |
| SCHEMBL4081701 | 0.91 | MAPK8 (0.64) | MAPK8PTGER4PTGER2KMT2ALMNA | |
| SCHEMBL4087178 | 0.85 | MAPK8 (0.69) | MAPK8PTGER4KMT2ALMNAHPGD | |
| SCHEMBL7317640 | 0.84 | MAPK8 (0.75) | MAPK8PTGER4PTGER2KMT2ALMNA | |
| SCHEMBL4085497 | 0.83 | PTGER4 (0.60) | MAPK8PTGER4LMNAHPGDSMN1; SMN2 | |
| SCHEMBL7371983 | 0.83 | MAPK8 (0.69) | MAPK8PTGER4PTGER2KMT2ALMNA | |
| SCHEMBL7168843 | 0.81 | MAPK8 (0.72) | MAPK8PTGER4KMT2A | |
| SCHEMBL4085475 | 0.80 | MAPK8 (0.62) | MAPK8PTGER4KMT2ALMNAHPGD | |
| SCHEMBL4086021 | 0.80 | MAPK8 (0.59) | MAPK8PTGER4LMNAHPGDSMN1; SMN2 | |
| SCHEMBL7371446 | 0.80 | LMNA (0.72) | MAPK8KMT2ALMNAHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651222-A1 | MEDICAMENTS COMPRISING PDE IV INHIBITORS AND AN ANTICHOLINERGIC FOR TREATING RESPIRATORY DISORDERS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2006-05-03 | — | — | EP | claimed |
| WO-2005013993-A1 | MEDICAMENTS COMPRISING PDE IV INHIBITORS AND AN ANTICHOLINERGIC FOR TREATING RESPIRATORY DISORDERS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-02-17 | — | — | WO | claimed |