SCHEMBL6049481

SCHEMBL6049481

c1cc(-n2cccn2)c2ocnc2c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 2/20 0.46
NPC1 O15118 1/20 0.46
KDM4E B2RXH2 3/20 0.40
ALDH1A1 P00352 3/20 0.40
LMNA P02545 3/20 0.40
MEN1 O00255 1/20 0.40
GAA P10253 1/20 0.40
MAPT P10636 1/20 0.40
G6PD P11413 1/20 0.40
KMT2A Q03164 1/20 0.40
TDO2 P48775 1/20 0.38
ADRA1A P35348 2/20 0.36
ADRA2A P08913 1/20 0.36
HCRTR2 O43614 3/20 0.35
HCRTR1 O43613 1/20 0.35
NOTUM Q6P988 1/20 0.35
HTT P42858 2/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
MTNR1A P48039 2/20 0.33
MTNR1B P49286 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4341886 0.70 MAPK1 (0.67) MAPK1NPC1KDM4EALDH1A1LMNA
Benzo[D]Oxazole SCHEMBL6850978 0.69 NOTUM (0.44) MAPK1NPC1KDM4EALDH1A1LMNA
SCHEMBL7090787 0.69 CA12 (0.37) MTNR1AMTNR1BELANE
SCHEMBL4332969 0.68 MAPK1 (0.64) MAPK1NPC1KDM4EALDH1A1LMNA
Hydrochloric Acid SCHEMBL4336588 0.68 MAPK1 (0.64) MAPK1NPC1KDM4EALDH1A1LMNA
Hydrochloric Acid SCHEMBL4340576 0.68 MAPK1 (0.64) MAPK1NPC1KDM4EALDH1A1LMNA
SCHEMBL26684295 0.68 CRBN (0.42) ELANE
SCHEMBL24755227 0.67 HTR3A (0.49) KDM4EALDH1A1
SCHEMBL10258863 0.67 NPC1 (0.57) MAPK1NPC1KDM4EALDH1A1LMNA
Hydrochloric Acid SCHEMBL4340573 0.67 MAPK1 (0.62) MAPK1NPC1KDM4EALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1458237-B1 HERBICIDAL MIXTURE BASED ON 7-PYRAZOLYLBENZOXAZOLES BASF AG (DE) 2006-04-12 EP claimed
US-20050037923-A1 Herbicidal mixture based on 7-pyrazolybenzoxazoles BASF AKTIENGESELLSCHAFT (DE) 2005-02-17 US claimed
EP-1458237-A1 HERBICIDAL MIXTURE BASED ON 7-PYRAZOLYLBENZOXAZOLES BASF AKTIENGESELLSCHAFT (DE) 2004-09-22 EP claimed
WO-2003051122-A1 HERBICIDAL MIXTURE BASED ON 7-PYRAZOLYLBENZOXAZOLES BASF AKTIENGESELLSCHAFT (DE) 2003-06-26 WO claimed
CN-1324962-C Herbicidal mixtures based on 7-pyrazolylbenzo\\58743zole BASF AG (DE) 2007-07-11 CN disclosed
CN-1324962-C Herbicidal mixtures based on 7-pyrazolylbenzo\\58743zole BASF AG (DE) 2007-07-11 CN disclosed
EP-1458237-B1 HERBICIDAL MIXTURE BASED ON 7-PYRAZOLYLBENZOXAZOLES BASF AG (DE) 2006-04-12 EP disclosed
EP-1458237-B1 HERBICIDAL MIXTURE BASED ON 7-PYRAZOLYLBENZOXAZOLES BASF AG (DE) 2006-04-12 EP disclosed
CN-1606407-A Herbicidal mixture based on 7-pyrazolybenzoxazoles BASF AG (DE) 2005-04-13 CN disclosed
CN-1606407-A Herbicidal mixture based on 7-pyrazolybenzoxazoles BASF AG (DE) 2005-04-13 CN disclosed
US-20050037923-A1 Herbicidal mixture based on 7-pyrazolybenzoxazoles BASF AKTIENGESELLSCHAFT (DE) 2005-02-17 US disclosed
US-20050037923-A1 Herbicidal mixture based on 7-pyrazolybenzoxazoles BASF AKTIENGESELLSCHAFT (DE) 2005-02-17 US disclosed
US-20050037923-A1 Herbicidal mixture based on 7-pyrazolybenzoxazoles BASF AKTIENGESELLSCHAFT (DE) 2005-02-17 US disclosed
EP-1458237-A1 HERBICIDAL MIXTURE BASED ON 7-PYRAZOLYLBENZOXAZOLES BASF AKTIENGESELLSCHAFT (DE) 2004-09-22 EP disclosed
EP-1458237-A1 HERBICIDAL MIXTURE BASED ON 7-PYRAZOLYLBENZOXAZOLES BASF AKTIENGESELLSCHAFT (DE) 2004-09-22 EP disclosed
WO-2003051122-A1 HERBICIDAL MIXTURE BASED ON 7-PYRAZOLYLBENZOXAZOLES BASF AKTIENGESELLSCHAFT (DE) 2003-06-26 WO disclosed
WO-2003051122-A1 HERBICIDAL MIXTURE BASED ON 7-PYRAZOLYLBENZOXAZOLES BASF AKTIENGESELLSCHAFT (DE) 2003-06-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050037923-A1 Herbicidal mixture based on 7-pyrazolybenzoxazoles DDT, CYP2W1, CYP3A7 MAPK1 2615/4885NPC1 4864/4885KDM4E 3461/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.