Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Sulfuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CA5A | P35218 | 1/20 | 0.33 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.33 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.33 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL689417 | 0.85 | — | — | |
| Hydrochloric Acid SCHEMBL6777486 | 0.82 | — | — | |
| Sulfuric Acid SCHEMBL11555534 | 0.75 | HSD17B10 (0.44) | BLMKDM4ENPSR1HSD17B10PMP22 | |
| Sulfuric Acid SCHEMBL11555536 | 0.75 | HSD17B10 (0.44) | BLMKDM4ENPSR1HSD17B10PMP22 | |
| Sulfuric Acid SCHEMBL6598917 | 0.75 | MEN1 (0.64) | BLMNPSR1PMP22ALOX15MEN1 | |
| Sulfuric Acid SCHEMBL11558562 | 0.74 | NOS1 (0.48) | BLMKDM4ENPSR1HSD17B10PMP22 | |
| Sulfuric Acid SCHEMBL11558559 | 0.74 | NOS1 (0.48) | BLMKDM4ENPSR1HSD17B10PMP22 | |
| Sulfuric Acid SCHEMBL11562779 | 0.74 | NPSR1 (0.47) | BLMKDM4ENPSR1HSD17B10PMP22 | |
| Sulfuric Acid SCHEMBL11557630 | 0.74 | MEN1 (0.75) | BLMNPSR1PMP22ALOX15MEN1 | |
| Sulfuric Acid SCHEMBL11562775 | 0.74 | NPSR1 (0.47) | BLMKDM4ENPSR1HSD17B10PMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117865165-B | Preparation method and application of ultra-small particle and high-stability silicon dioxide colloid | 山东科翰硅源新材料有限公司 | 2024-09-17 | — | — | CN | disclosed |
| CN-117865165-A | Preparation method and application of ultra-small particle and high-stability silicon dioxide colloid | 山东科翰硅源新材料有限公司 | 2024-04-12 | — | — | CN | disclosed |
| CN-111978262-B | Synthesis method of hydroxypyrimidine compound | 西安近代化学研究所 | 2023-07-18 | — | — | CN | disclosed |
| CN-115403527-A | Method for synthesizing bactericide ethirimol by reductive amination method | 西安近代化学研究所 | 2022-11-29 | — | — | CN | disclosed |
| CN-111978262-A | Synthetic method of hydroxypyrimidine compound | 西安近代化学研究所 | 2020-11-24 | — | — | CN | disclosed |
| EP-1681058-A2 | Pharmacologically active cns compounds | THE WELLCOME FOUNDATION LIMITED (GB) | 2006-07-19 | — | — | EP | disclosed |
| EP-1325916-A1 | Piperazinyl-substituted phenyl pyrimidine derivatives useful in the treatment or prevention of disorders of the central nervous system | THE WELLCOME FOUNDATION LIMITED (GB) | 2003-07-09 | — | — | EP | disclosed |
| EP-0859762-A1 | CYTOKINE PRODUCTION INHIBITORS, FORMULATIONS THEREOF AND THEIR USE IN MEDICINE, AND METHODS FOR THEIR IDENTIFICATION | WIVENHOE TECHNOLOGY LIMITED (GB) | 1998-08-26 | — | — | EP | disclosed |
| US-5712276-A | TREATING NERVOUS SYSTEM DISORDERS | GLAXO WELLCOME INC. (US) | 1998-01-27 | — | — | US | disclosed |
| WO-1997045417-A1 | CYTOKINE PRODUCTION INHIBITORS, FORMULATIONS THEREOF AND THEIR USE IN MEDICINE, AND METHODS FOR THEIR IDENTIFICATION | WIVENHOE TECHNOLOGY LIMITED (GB) | 1997-12-04 | — | — | WO | disclosed |
| EP-0715851-A2 | Substituted phenylpyrimidine derivatives, useful in the treatment of prevention of CNS disorders | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-06-12 | — | — | EP | disclosed |
| EP-0713703-A2 | Substituted phenylpyrimidine derivatives, useful in the treatment or prevention of CNS disorders | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-05-29 | — | — | EP | disclosed |
| US-5136080-A | Intermediates for glutamate inhibitors | BURROUGHS WELLCOME CO. (US) | 1992-08-04 | — | — | US | disclosed |
| EP-0372934-A2 | Pharmacologically active CNS compounds | THE WELLCOME FOUNDATION LIMITED (GB) | 1990-06-13 | — | — | EP | disclosed |
| US-4544670-A | ANTIPROTOZOA AGENTS, GASTROINTESTINAL AND CARDIOVASCULAR DISORDERS | WILLIAM H. RORER, INC. (US) | 1985-10-01 | — | — | US | disclosed |
| EP-0116639-A4 | ACYL GUANIDINES. | RORER INTERNAT OVERSEAS INC (US) | 1985-09-25 | — | — | EP | disclosed |
| EP-0116639-A1 | ACYL GUANIDINES | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1984-08-29 | — | — | EP | disclosed |
| WO-1984000875-A1 | ACYL GUANIDINES | RORER INT OVERSEAS (US) | 1984-03-15 | — | — | WO | disclosed |
| US-4147804-A | ANTIARRHYTHMIA AGENTS | WILLIAM H. RORER, INC. (US) | 1979-04-03 | — | — | US | disclosed |
| US-3948912-A | ANTIBACTERIAL, ANTIPROTOZOA | BOEHRINGER MANNHEIM G.M.B.H. (DT) | 1976-04-06 | — | — | US | disclosed |