Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | KDR | P35968 | 2/20 | 0.52 |
| ▸ | BRAF | P15056 | 1/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.52 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.52 |
| ▸ | KDM1A | O60341 | 1/20 | 0.52 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | MITF | O75030 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | F13A1 | P00488 | 1/20 | 0.51 |
| ▸ | TGM2 | P21980 | 1/20 | 0.51 |
| ▸ | PLAU | P00749 | 1/20 | 0.49 |
| ▸ | F10 | P00742 | 1/20 | 0.48 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.48 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4089354 | 0.87 | MITF (0.65) | ALDH1A1HTTMITFPOLBMAPK1 | |
| SCHEMBL18666241 | 0.84 | ALDH1A1 (0.58) | RAF1ALDH1A1KDRBRAFMAPK14 | |
| SCHEMBL5008975 | 0.82 | HSD17B10 (0.58) | RAF1ALDH1A1KDRBRAFMAPK14 | |
| SCHEMBL4092538 | 0.82 | CDK8 (0.58) | RAF1ALDH1A1HTTMITFPOLB | |
| SCHEMBL4082468 | 0.82 | ALDH1A1 (0.55) | ALDH1A1HTTMITFPOLBMAPK1 | |
| SCHEMBL30396799 | 0.81 | KCNK3 (0.71) | RAF1KDRHTTMAPK1PLAU | |
| SCHEMBL24004043 | 0.81 | HPSE (0.56) | RAF1ALDH1A1BRAFKDM1ARCOR1 | |
| SCHEMBL24010179 | 0.80 | HDAC3 (0.56) | RAF1BRAFKDM1ARCOR1HTT | |
| SCHEMBL6049520 | 0.80 | BTK (0.48) | RAF1ALDH1A1KDRMAPK1F10 | |
| SCHEMBL13648115 | 0.79 | RAF1 (0.50) | RAF1ALDH1A1KDRBRAFMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1041982-A4 | INHIBITION OF p38 KINASE ACTIVITY USING SUBSTITUTED HETEROCYCLIC UREAS | BAYER PHARMACEUTICALS CORP (US) | 2006-06-14 | — | — | EP | disclosed |
| EP-1041982-A1 | INHIBITION OF p38 KINASE ACTIVITY USING SUBSTITUTED HETEROCYCLIC UREAS | Bayer Corporation (US) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999032111-A1 | INHIBITION OF p38 KINASE ACTIVITY USING SUBSTITUTED HETEROCYCLIC UREAS | BAYER CORPORATION (US) | 1999-07-01 | — | — | WO | disclosed |