SCHEMBL6050976

SCHEMBL6050976

Cc1cc(CNS(=O)(=O)C2(N(C(=O)O)C(C)(C)C)CC2)no1

nearest known ligand 0.39

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
EPHX2 P34913 1/20 0.39
NPC1 O15118 1/20 0.34
RAB9A P51151 1/20 0.34
CYP1A2 P05177 2/20 0.33
CYP2D6 P10635 1/20 0.33
CYP2C19 P33261 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
BMP1 P13497 1/20 0.32
FPR3 P25089 1/20 0.32
FPR2 P25090 1/20 0.32
ADORA2A P29274 1/20 0.32
ADORA1 P30542 1/20 0.32
LMNA P02545 2/20 0.32
PTGS2 P35354 1/20 0.32
ALDH1A1 P00352 1/20 0.32
TSHR P16473 1/20 0.32
EDNRA P25101 1/20 0.31
CNR2 P34972 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6050996 0.80 MEN1 (0.39) ALDH1A1EDNRA
SCHEMBL6050991 0.75 SMN1; SMN2 (0.41) RAB9ASMN1; SMN2LMNAALDH1A1
SCHEMBL4983531 0.70 EPHX2 (0.34) EPHX2SMN1; SMN2BMP1LMNAALDH1A1
SCHEMBL6050958 0.70 ATM (0.39) CYP2D6CYP2C19SMN1; SMN2LMNAALDH1A1
SCHEMBL2844130 0.68 EPHX2 (0.43) EPHX2NPC1RAB9ACYP1A2CYP2D6
SCHEMBL2755867 0.67 EPHX2 (0.58) EPHX2NPC1RAB9ACYP1A2CYP2D6
SCHEMBL6050977 0.66 ALDH1A1 (0.33) LMNAALDH1A1
SCHEMBL16133691 0.65 EPHX2 (0.53) EPHX2NPC1RAB9ACYP1A2CYP2D6
SCHEMBL6568083 0.65 ALDH1A1 (0.54) CYP1A2CYP2D6CYP2C19SMN1; SMN2LMNA
SCHEMBL23576399 0.64 EPHX2 (0.56) EPHX2NPC1RAB9ACYP1A2CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1505945-A4 SUBSTITUTED CYCLOALKYL P1' HEPATITIS C VIRUS INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2006-11-22 EP disclosed
EP-1505945-A2 SUBSTITUTED CYCLOALKYL P1' HEPATITIS C VIRUS INHIBITORS Bristol-Myers Squibb Pharma Company (US) 2005-02-16 EP disclosed
WO-2004043339-A2 SUBSTITUTED CYCLOALKYL P1' HEPATITIS C VIRUS INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2004-05-27 WO disclosed