Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 8/20 | 0.71 |
| ▸ | PDE3A | Q14432 | 8/20 | 0.71 |
| ▸ | PDE2A | O00408 | 1/20 | 0.57 |
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6052812 | 1.00 | PDE3B (0.71) | PDE3BPDE3APDE2AGPR119MAPT | |
| SCHEMBL11046458 | 0.90 | PDE3B (0.71) | PDE3BPDE3APDE2AMAPTSMN1; SMN2 | |
| SCHEMBL10735939 | 0.85 | PDE3B (0.52) | PDE3BPDE3APDE2AGPR119MAPT | |
| SCHEMBL3723998 | 0.83 | PDE3B (1.00) | PDE3BPDE3AMAPTSMN1; SMN2KDM4E | |
| SCHEMBL3723997 | 0.83 | PDE3B (1.00) | PDE3BPDE3AMAPTSMN1; SMN2KDM4E | |
| SCHEMBL10762953 | 0.82 | SMN1; SMN2 (0.57) | PDE3BPDE3APDE2AGPR119MAPT | |
| SCHEMBL10619119 | 0.82 | PDE3B (0.51) | PDE3BPDE3APDE2AGPR119MAPT | |
| SCHEMBL9686762 | 0.81 | GPR119 (0.66) | PDE3BPDE3APDE2AGPR119 | |
| Methylamine SCHEMBL10474969 | 0.81 | PDE3B (0.95) | PDE3BPDE3AMAPTSMN1; SMN2KDM4E | |
| Dimethylamine SCHEMBL10475180 | 0.81 | PDE3B (0.95) | PDE3BPDE3AMAPTSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7045147-B1 | Controlled release peroral compositions of levosimendan | ORION CORPORATION (FI) | 2006-05-16 | — | — | US | disclosed |
| EP-1071397-B1 | CONTROLLED RELEASE PERORAL COMPOSITIONS OF LEVOSIMENDAN | ORION CORP (FI) | 2004-01-28 | — | — | EP | disclosed |
| EP-1071397-A2 | CONTROLLED RELEASE PERORAL COMPOSITIONS OF LEVOSIMENDAN | ORION CORPORATION (FI) | 2001-01-31 | — | — | EP | disclosed |
| WO-1999055305-A2 | CONTROLLED RELEASE PERORAL COMPOSITIONS OF LEVOSIMENDAN | ORION CORPORATION (FI) | 1999-11-04 | — | — | WO | disclosed |
| WO-1999056134-A1 | A METHOD FOR MONITORING THE TOLERABILITY OF LEVOSIMENDAN ADMINISTRATION | ORION CORPORATION (FI) | 1999-11-04 | — | — | WO | disclosed |